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| Sponsored by: |
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
| Information provided by: | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
| ClinicalTrials.gov Identifier: | NCT00033826 |
Purpose
Vitamin D is a fat soluble vitamin that has important effects on calcium (including absorption of calcium from the diet) and bone metabolism. Vitamin D is known to be stored in fat tissue, and it is also present in the circulation. The purpose of this study is to investigate the relationship between levels of vitamin D in fat tissue and in blood.
| Condition |
|
Vitamin D Adipose Tissue |
| Drug Information available for: | Vitamin D Ergocalciferol |
| Study Type: | Observational |
| Study Design: | Case-Only, Cross-Sectional |
| Official Title: | The Role of Adipose Tissue in Vitamin D Metabolism |
| Enrollment: | 41 |
| Study Start Date: | April 2002 |
| Study Completion Date: | September 2007 |
| Primary Completion Date: | September 2007 (Final data collection date for primary outcome measure) |
Although vitamin D is known to be stored in fat tissue, researchers are not sure about the role that fat tissue plays in vitamin D metabolism. This study will help develop the methodology necessary to further investigate the role of fat tissue in vitamin D metabolism and will assess the relationship between levels of vitamin D in fat tissue and in blood. 50 subjects who are referred for gastric bypass surgery will be enrolled in this study. Subjects will complete questionnaires about their medical history, travel history and food intake. Prior to or during surgery, subjects will be asked to provide a blood sample for selected chemistries related to vitamin D metabolism. During gastric bypass surgery, the surgeon will collect small pieces of fat tissue from the fat under the skin and within the abdomen by surgical biopsy. These samples will be used to refine the methodology for determining the levels of vitamin D in blood and fat tissue and for comparing levels of vitamin D in various tissues.
Eligibility
| Ages Eligible for Study: | 18 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
patients from Obesity Clinic
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| United States, Massachusetts | |||||
| Tufts-New England Medical Center | |||||
| Boston, Massachusetts, United States, 02111 | |||||
| Principal Investigator: | Miriam Blum, MD | Jean Mayer USDA Human Nutrition Center on Aging at Tufts University |
More Information
| Responsible Party: | HNRC at Tufts ( Miriam Blum, MD ) |
| Study ID Numbers: | K23 AR47869, NIAMS-070 |
| First Received: | April 10, 2002 |
| Last Updated: | March 12, 2008 |
| ClinicalTrials.gov Identifier: | NCT00033826 |
| Health Authority: | United States: Federal Government |
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