Evaluation of Echinacea for the Common Cold
The purpose of this study is to determine whether three Echinacea preparations with different chemical compositions are effective for prevention or treatment of the common cold.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Prevention
|Official Title:||Evaluation of Echinacea in a Human Rhinovirus Challenge|
|Study Start Date:||September 2001|
|Estimated Study Completion Date:||May 2004|
Echinacea is a widely used herbal remedy for the common cold. Previous clinical trials designed to assess the efficacy of Echinacea for prevention or treatment of the common cold have produced inconsistent results. A variety of different Echinacea products have been used in these clinical trials. Recent studies indicate that different Echinacea preparations have dramatically different phytochemical profiles. The available clinical trial data provide no information about the potential role of the different constituents of Echinacea in common cold prevention or treatment. Our hypothesis is that the variation in reported clinical effectiveness may be due to differences in the phytochemical profile of the Echinacea preparations used. This study will address the following specific aims: 1) Evaluate the effectiveness of chemically defined extracts of E. angustifolia root which contain alkamides, echinacoside or polysaccharidelglycoprotein for common cold prevention or treatment; 2) Assess the correlation between specific Echinacea metabolites in serum and nasal secretions and efficacy for prevention and treatment of colds; and 3) Determine the effect of different Echinacea preparations on the host response to rhinovirus infection.
|United States, Virginia|
|University of Virginia, Charlottesville|
|Charlottesville, Virginia, United States, 22904|
|Principal Investigator:||Ronald B. Turner, MD||University of Virginia School of Medicine|
|Investigator:||J. David Gangemi, PhD||Clemson University|
|Investigator:||Rudolf Bauer, PhD||Karl-Franzens-Universitaet Graz|