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| Sponsors and Collaborators: |
Societe Internationale d'Oncologie Pediatrique Children's Cancer and Leukaemia Group Societe Francaise Oncologie Pediatrique |
| Information provided by: | National Cancer Institute (NCI) |
| ClinicalTrials.gov Identifier: | NCT00025441 |
Purpose
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating children with metastatic rhabdomyosarcoma or other malignant mesenchymal tumors.
| Condition | Intervention | Phase |
|
Ovarian Cancer Sarcoma Small Intestine Cancer |
Drug: carboplatin Drug: cyclophosphamide Drug: dactinomycin Drug: doxorubicin hydrochloride Drug: epirubicin hydrochloride Drug: etoposide Drug: filgrastim Drug: ifosfamide Drug: vincristine sulfate Procedure: peripheral blood stem cell transplantation Procedure: radiation therapy |
Phase II |
| MedlinePlus related topics: | Cancer Intestinal Cancer Ovarian Cancer Soft Tissue Sarcoma |
| Study Type: | Interventional |
| Study Design: | Treatment |
| Official Title: | MMT 98 Study For Metastatic Disease Rhabdomyosarcoma And Other Malignant Soft Tissue Sarcoma Of Childhood |
Eligibility
| Ages Eligible for Study: | 6 Years to 17 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Histologically confirmed metastatic rhabdomyosarcoma or other malignant mesenchymal tumors
Standard risk defined as:
High risk defined as:
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy:
Surgery:
Contacts and Locations| France | |||||
| Centre Leon Berard | |||||
| Lyon, France, 69373 | |||||
| Ireland | |||||
| Our Lady's Hospital for Sick Children | |||||
| Crumlin, Ireland, 12 | |||||
| United Kingdom, England | |||||
| Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust | |||||
| Cambridge, England, United Kingdom, CB2 2QQ | |||||
| Birmingham Children's Hospital | |||||
| Birmingham, England, United Kingdom, B4 6NH | |||||
| Bristol Royal Hospital for Children | |||||
| Bristol, England, United Kingdom, BS2 8BJ | |||||
| Meyerstein Institute of Oncology at University College of London Hospitals | |||||
| London, England, United Kingdom, WIT 3AA | |||||
| Children's Hospital - Sheffield | |||||
| Sheffield, England, United Kingdom, S10 2TH | |||||
| Great Ormond Street Hospital for Children NHS Trust | |||||
| London, England, United Kingdom, WC1N 3JH | |||||
| Leeds Cancer Centre at St. James's University Hospital | |||||
| London, England, United Kingdom, W6 8RF | |||||
| Leicester Royal Infirmary | |||||
| Leicester, England, United Kingdom, LE1 5WW | |||||
| Central Manchester and Manchester Children's University Hospitals NHS Trust | |||||
| Manchester, England, United Kingdom, M27 4HA | |||||
| Newcastle Upon Tyne Hospitals NHS Trust | |||||
| Newcastle-Upon-Tyne, England, United Kingdom, NE7 7DN | |||||
| Oxford Radcliffe Hospital | |||||
| Oxford, England, United Kingdom, 0X3 9DU | |||||
| Queen's Medical Centre | |||||
| Nottingham, England, United Kingdom, NG7 2UH | |||||
| Royal Liverpool Children's Hospital, Alder Hey | |||||
| Liverpool, England, United Kingdom, L12 2AP | |||||
| Royal Marsden NHS Foundation Trust - Surrey | |||||
| Sutton, England, United Kingdom, SM2 5PT | |||||
| Saint Bartholomew's Hospital | |||||
| London, England, United Kingdom, EC1A 7BE | |||||
| Southampton General Hospital | |||||
| Southampton, England, United Kingdom, SO16 6YD | |||||
| United Kingdom, Northern Ireland | |||||
| Royal Belfast Hospital for Sick Children | |||||
| Belfast, Northern Ireland, United Kingdom, BT12 6BE | |||||
| United Kingdom, Scotland | |||||
| Aberdeen Royal Infirmary | |||||
| Aberdeen, Scotland, United Kingdom, AB25 2ZN | |||||
| Royal Hospital for Sick Children | |||||
| Glasgow, Scotland, United Kingdom, G3 8SJ | |||||
| Royal Hospital for Sick Children | |||||
| Edinburgh, Scotland, United Kingdom | |||||
| Societe Internationale d'Oncologie Pediatrique |
| Children's Cancer and Leukaemia Group |
| Societe Francaise Oncologie Pediatrique |
| Study Chair: | Heather P. McDowell, MD | Royal Liverpool Children's Hospital, Alder Hey |
| Study Chair: | Annabel B.M. Foot | Bristol Royal Hospital for Children |
| Study Chair: | Christophe Bergeron | Centre Leon Berard |
More Information
Clinical trial summary from the National Cancer Institute's PDQ® database 
  |
| Study ID Numbers: | CDR0000068961, SIOP-MMT-98, SFOP-SIOP-MMT-98, CCLG-SIOP-MMT-98, EU-20126, STS-1998 |
| First Received: | October 11, 2001 |
| Last Updated: | August 23, 2008 |
| ClinicalTrials.gov Identifier: | NCT00025441 |
| Health Authority: | United States: Federal Government |
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