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| Sponsored by: |
National Institute of Environmental Health Sciences (NIEHS) |
| Information provided by: | National Institute of Environmental Health Sciences (NIEHS) |
| ClinicalTrials.gov Identifier: | NCT00023140 |
Purpose
Butadiene is a suspect human carcinogen to which most people are exposed daily. Exposures are difficult to measure by air sampling. This study examines the relationship between air levels and several biomarkers of exposure. Biomarkers are substances analyzed in human tissues or waste products. Adducts are materials formed when a chemical reacts with a biological material. In this study we are looking at biomarkers in the blood: hemoglobin and DNA adducts, and urinary metabolites. If a strong relationship is found then the amounts of biomarkers in a person's blood or urine can tell us how much they have been exposed. The tests are being conducted on petrochemical workers who have a wide range of exposures to butadiene. An international group of investigators is conducting the study.
| Condition |
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Cancer |
| Genetics Home Reference related topics: | Benign Tumors Cancer |
| Study Type: | Observational |
| Study Design: | Natural History, Longitudinal, Defined Population, Prospective Study |
Eligibility
| Ages Eligible for Study: | 19 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Healthy adults without metabolic disorders
Contacts and Locations More Information
| Study ID Numbers: | 9401-CP-001 |
| First Received: | August 22, 2001 |
| Last Updated: | March 22, 2006 |
| ClinicalTrials.gov Identifier: | NCT00023140 |
| Health Authority: | United States: Federal Government |
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