Study of Taste Deficits - Full Text View

Sponsor:	National Institute on Deafness and Other Communication Disorders (NIDCD)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00022997

Purpose

This study will explore the genetics of taste and taste deficits. The sense of taste plays a crucial role in food choices, allowing people to identify beneficial foods (those with high caloric value, which are typically sweet) and foods likely to be toxic (usually bitter substances). The loss of sense of taste in older people plays a role in decreased appetite and poor nutrition. Taste deficits may adversely affect people in ways that are not well understood. This study will examine why some people (about one-fourth of all people in the United States) cannot taste a substance called phenylthiocarbamide (PTC). The inability to taste PTC is due to inherited factors that are not yet clear.

Individuals age 18 and older who can taste PTC and individuals who cannot taste PTC may be eligible for this study. Participants will taste a number of liquid solutions until they find one with a clear taste. Then they will taste another group of solutions and decide which ones have that taste and which have no taste. Finally, they will taste a third group of solutions until they find one with a different taste. About 2 tablespoons of blood will be drawn from participants for genetic tests related to the sense of taste.

Condition
Taste Disorder Healthy

Study Type:	Observational
Official Title:	Studies of Deficits in the Sense of Taste

Resource links provided by NLM:

MedlinePlus related topics: Taste and Smell Disorders

U.S. FDA Resources

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	400
Study Start Date:	August 2001
Estimated Primary Completion Date:	June 2011 (Final data collection date for primary outcome measure)

Detailed Description:

The primary goal of this study is to identify the underlying cause of deficits in the ability to taste different commonly consumed substances, including the bitter compound phenylthiocarbamide (PTC) as a model. Individuals will be tested to identify those who can and cannot taste PTC, as well as for their ability to taste a variety of sweet, sour, salty, and savory substances. Individuals will have 20 cc of blood drawn to obtain DNA. These DNA samples will then be analyzed for variation in genes whose products are known to be involved in taste perception pathways. Information about individuals' DNA sequence variation will then be correlated with their taste phenotype to identify the specific genetic variation that causes phenotypic variation, providing molecular structure-function information in taste sensory pathways.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

INCLUSION CRITERIA:

This study includes medically normal individuals age 18 and older. This study includes both males and females, and includes members of all racial and ethnic groups. This study includes both individuals with a normal sense of taste, those unable to taste PTC, and those with varying degrees of taste sensitivity for other taste substances.

EXCLUSION CRITERIA:

Individuals excluded will be those under age 18, those who are cognitively impaired, those with a physical impairment in swallowing, those who have general impairments in the sense of taste, those currently using psychoactive medication, prisoners, or other at-risk populations.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00022997

Contacts

Contact: Patient Recruitment and Public Liaison Office	(800) 411-1222	prpl@mail.cc.nih.gov
Contact: TTY	1-866-411-1010

Locations

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike	Recruiting
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Institute on Deafness and Other Communication Disorders (NIDCD)

More Information

Additional Information:

NIH Clinical Center Detailed Web Page This link exits the ClinicalTrials.gov site

Publications:

Reddy BM, Rao DC. Phenylthiocarbamide taste sensitivity revisited: complete sorting test supports residual family resemblance. Genet Epidemiol. 1989;6(3):413-21.

Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS. A novel family of mammalian taste receptors. Cell. 2000 Mar 17;100(6):693-702.

Conneally PM, Dumont-Driscoll M, Huntzinger RS, Nance WE, Jackson CE. Linkage relations of the loci for Kell and phenylthiocarbamide taste sensitivity. Hum Hered. 1976;26(4):267-71.

Study ID Numbers:	010230, 01-DC-0230
Study First Received:	August 17, 2001
Last Updated:	August 24, 2009
ClinicalTrials.gov Identifier:	NCT00022997 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Phenylthiocarbamide
Phlebotomy
Chemoreceptors
Population Associations
Non-tasters

Taste
Healthy Volunteer
HV
Normal Control

Additional relevant MeSH terms:

Signs and Symptoms
Sensation Disorders
Taste Disorders
Nervous System Diseases
Neurologic Manifestations

ClinicalTrials.gov processed this record on November 05, 2009