Treating Alcohol Use In Older Adults With Depression - Full Text View

Purpose

The purpose of this study is to test the efficacy combining a treatment for depression with a treatment for alcohol dependence.

Condition	Intervention	Phase
Alcoholism Depression	Drug: NALTREXONE	Phase IV

MedlinePlus related topics:

Alcoholism Depression

ChemIDplus related topics:

Naltrexone Naltrexone hydrochloride Ethanol

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Efficacy Study

Official Title:	The Treatment of Late Life Major Depression Complication by Alcohol

Further study details as provided by Department of Veterans Affairs:

Study Start Date:	October 1999
Estimated Study Completion Date:	October 2002

Detailed Description:

This study aims to study 80 patients with comorbid alcohol dependence and a depressive syndrome. After appropriate detoxification, patients are started on either naltrexone 50 mg or placebo. After one week, sertraline is added in an open label fashion. It is hypothesized that those patients receiving combination therapy will last 3 months with follow-up tracking lasting 1 year.

Eligibility

Ages Eligible for Study:	55 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Age > 55
Current depressive syndrome
Current alcohol dependence
No psychosis
No opioid or cocaine abuse or dependence

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00018824

Locations


United States, Pennsylvania
	Philadelphia Vamc
	Philadelphia, Pennsylvania, United States, 19104

Sponsors and Collaborators

Department of Veterans Affairs

More Information

Study ID Numbers:	MHBS-009-98S
First Received:	July 3, 2001
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00018824
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Depression

Disorders of Environmental Origin

Depressive Disorder, Major

Depressive Disorder

Alcohol Drinking

Behavioral Symptoms

Mental Disorders

Alcoholism

Naltrexone

Substance-Related Disorders

Mood Disorders

Alcohol-Related Disorders

Ethanol

Additional relevant MeSH terms:

Sensory System Agents

Therapeutic Uses

Physiological Effects of Drugs

Narcotic Antagonists

Peripheral Nervous System Agents

Central Nervous System Agents

Pharmacologic Actions

ClinicalTrials.gov processed this record on October 07, 2008

Sponsored by:	Department of Veterans Affairs
Information provided by:	Department of Veterans Affairs
ClinicalTrials.gov Identifier:	NCT00018824