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Treating Alcohol Use In Older Adults With Depression

This study has been completed.

Sponsored by: Department of Veterans Affairs
Information provided by: Department of Veterans Affairs
ClinicalTrials.gov Identifier: NCT00018824
  Purpose

The purpose of this study is to test the efficacy combining a treatment for depression with a treatment for alcohol dependence.


Condition Intervention Phase
Alcoholism
Depression
Drug: NALTREXONE
Phase IV

MedlinePlus related topics:   Alcoholism    Depression   

ChemIDplus related topics:   Naltrexone    Naltrexone hydrochloride    Ethanol   

U.S. FDA Resources

Study Type:   Interventional
Study Design:   Treatment, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Efficacy Study
Official Title:   The Treatment of Late Life Major Depression Complication by Alcohol

Further study details as provided by Department of Veterans Affairs:

Study Start Date:   October 1999
Estimated Study Completion Date:   October 2002

Detailed Description:

This study aims to study 80 patients with comorbid alcohol dependence and a depressive syndrome. After appropriate detoxification, patients are started on either naltrexone 50 mg or placebo. After one week, sertraline is added in an open label fashion. It is hypothesized that those patients receiving combination therapy will last 3 months with follow-up tracking lasting 1 year.

  Eligibility
Ages Eligible for Study:   55 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Criteria
  • Age > 55
  • Current depressive syndrome
  • Current alcohol dependence
  • No psychosis
  • No opioid or cocaine abuse or dependence
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00018824

Locations
United States, Pennsylvania
Philadelphia Vamc    
      Philadelphia, Pennsylvania, United States, 19104

Sponsors and Collaborators
  More Information


Study ID Numbers:   MHBS-009-98S
First Received:   July 3, 2001
Last Updated:   June 23, 2005
ClinicalTrials.gov Identifier:   NCT00018824
Health Authority:   United States: Federal Government

Study placed in the following topic categories:
Depression
Disorders of Environmental Origin
Depressive Disorder, Major
Depressive Disorder
Alcohol Drinking
Behavioral Symptoms
Mental Disorders
Alcoholism
Naltrexone
Substance-Related Disorders
Mood Disorders
Alcohol-Related Disorders
Ethanol

Additional relevant MeSH terms:
Sensory System Agents
Therapeutic Uses
Physiological Effects of Drugs
Narcotic Antagonists
Peripheral Nervous System Agents
Central Nervous System Agents
Pharmacologic Actions

ClinicalTrials.gov processed this record on October 07, 2008




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