Biological Aspects of Depression and Antidepressant Drugs - Full Text View

Biological Aspects of Depression and Antidepressant Drugs

This study has been completed.

Sponsored by:	Department of Veterans Affairs
Information provided by:	Department of Veterans Affairs
ClinicalTrials.gov Identifier:	NCT00018733

Purpose

This study will be measuring changes in depressive symptoms over a 7 week time period. Double-blind placebo controlled trial using the pharmacologic agents Paroxetine or Desipramine.

Condition	Intervention
Depression	Drug: paroxetine Drug: Desipramine

MedlinePlus related topics:

Antidepressants Depression

ChemIDplus related topics:

Desipramine Desipramine hydrochloride Paroxetine Paroxetine hydrochloride Paroxetine Mesylate

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Pharmacodynamics Study

Official Title:	Biological Aspects of Depression and Antidepressant Drugs

Further study details as provided by Department of Veterans Affairs:

Study Start Date:	September 1996
Estimated Study Completion Date:	December 2001

Eligibility

Ages Eligible for Study:	21 Years to 69 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Diagnosis of major depressive disorder Ham-D Score > 18
English speaking with ability to read and sign an informed consent

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00018733

Locations


United States, Texas
	South Texas Veterans Health Care System
	San Antonio, Texas, United States, 78229

Sponsors and Collaborators

Department of Veterans Affairs

Investigators


Investigator:	Steve Brannan, M.D.

Investigator:	Cheryl Gonzalez, M.D.

More Information

Study ID Numbers:	MHBS-031-99F
First Received:	July 3, 2001
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00018733
Health Authority:	United States: Federal Government

Keywords provided by Department of Veterans Affairs:

Depression

Study placed in the following topic categories:

Depression

Mental Disorders

Mood Disorders

Desipramine

Depressive Disorder

Paroxetine

Serotonin

Behavioral Symptoms

Additional relevant MeSH terms:

Neurotransmitter Agents

Neurotransmitter Uptake Inhibitors

Molecular Mechanisms of Pharmacological Action

Adrenergic Agents

Adrenergic Uptake Inhibitors

Physiological Effects of Drugs

Psychotropic Drugs

Enzyme Inhibitors

Serotonin Uptake Inhibitors

Pharmacologic Actions

Antidepressive Agents, Tricyclic

Serotonin Agents

Therapeutic Uses

Antidepressive Agents, Second-Generation

Central Nervous System Agents

Antidepressive Agents

ClinicalTrials.gov processed this record on October 10, 2008