Biological Aspects of Depression and Antidepressant Drugs

This study has been completed.

First Received: July 3, 2001 Last Updated: January 20, 2009 History of Changes

Sponsored by:	Department of Veterans Affairs
Information provided by:	Department of Veterans Affairs
ClinicalTrials.gov Identifier:	NCT00018733

Purpose

This study will be measuring changes in depressive symptoms over a 7 week time period. Double-blind placebo controlled trial using the pharmacologic agents Paroxetine or Desipramine.

Condition	Intervention
Depression	Drug: paroxetine Drug: Desipramine

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Pharmacodynamics Study
Official Title:	Biological Aspects of Depression and Antidepressant Drugs

Resource links provided by NLM:

MedlinePlus related topics: Antidepressants Depression

Drug Information available for: Desipramine Desipramine hydrochloride Paroxetine Paroxetine hydrochloride Paroxetine Mesylate

U.S. FDA Resources

Further study details as provided by Department of Veterans Affairs:

Study Start Date:	September 1996
Estimated Study Completion Date:	December 2001

Eligibility

Ages Eligible for Study:	21 Years to 69 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Diagnosis of major depressive disorder Ham-D Score > 18
English speaking with ability to read and sign an informed consent

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00018733

Locations

United States, Texas
South Texas Veterans Health Care System
San Antonio, Texas, United States, 78229

Sponsors and Collaborators

Department of Veterans Affairs

Investigators

Investigator:	Steve Brannan, M.D.
Investigator:	Cheryl Gonzalez, M.D.

More Information

No publications provided

Study ID Numbers:	MHBS-031-99F
Study First Received:	July 3, 2001
Last Updated:	January 20, 2009
ClinicalTrials.gov Identifier:	NCT00018733 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by Department of Veterans Affairs:

Depression

Study placed in the following topic categories:

Neurotransmitter Agents
Depression
Adrenergic Agents
Psychotropic Drugs
Depressive Disorder
Desipramine
Serotonin Uptake Inhibitors
Paroxetine

Serotonin
Behavioral Symptoms
Antidepressive Agents, Tricyclic
Mental Disorders
Mood Disorders
Antidepressive Agents, Second-Generation
Antidepressive Agents

Additional relevant MeSH terms:

Neurotransmitter Uptake Inhibitors
Neurotransmitter Agents
Depression
Adrenergic Agents
Molecular Mechanisms of Pharmacological Action
Adrenergic Uptake Inhibitors
Physiological Effects of Drugs
Psychotropic Drugs
Enzyme Inhibitors
Depressive Disorder
Desipramine
Serotonin Uptake Inhibitors

Paroxetine
Pharmacologic Actions
Antidepressive Agents, Tricyclic
Behavioral Symptoms
Serotonin Agents
Mental Disorders
Therapeutic Uses
Mood Disorders
Antidepressive Agents, Second-Generation
Central Nervous System Agents
Antidepressive Agents

ClinicalTrials.gov processed this record on July 02, 2009