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Combinations of Pharmacologic Smoking Cessation Treatments

This study has been completed.

Sponsored by: Department of Veterans Affairs
Information provided by: Department of Veterans Affairs
ClinicalTrials.gov Identifier: NCT00018187
  Purpose

The purpose of this study is to test the effectiveness of a combination of the drugs bupropion and mecamylamine along with a nicotine patch as a therapy for smoking cessation.


Condition Intervention Phase
Smoking
Drug: Bupropion
Drug: Mecamylamine
Drug: Nicotine Patch
Phase I

MedlinePlus related topics:   Smoking    Smoking Cessation   

ChemIDplus related topics:   Bupropion hydrochloride    Bupropion    Nicotine polacrilex    Nicotine tartrate    Mecamylamine    Mecamylamine hydrochloride   

U.S. FDA Resources

Study Type:   Interventional
Study Design:   Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study
Official Title:   Combinations of Pharmacologic Smoking Cessation Treatments

Further study details as provided by Department of Veterans Affairs:

Study Start Date:   November 1998
Estimated Study Completion Date:   June 2001

  Eligibility
Ages Eligible for Study:   20 Years to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Criteria

Subjects must be a smoker between 20 and 40 years old, have smoked at least 20 cigarettes per day for at least 2 years, wish to stop smoking and be in good general health

  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00018187

Locations
United States, California
VA Greater Los Angeles Healthcare System    
      Los Angeles, California, United States, 90073

Sponsors and Collaborators

Investigators
Investigator:     Neil Hartman, M.D.    
  More Information

Study ID Numbers:   ADRD-011-98S
First Received:   July 3, 2001
Last Updated:   May 7, 2007
ClinicalTrials.gov Identifier:   NCT00018187
Health Authority:   United States: Food and Drug Administration

Keywords provided by Department of Veterans Affairs:
smoking cessation  
bupropion  
mecamylamine  
nicotine  

Study placed in the following topic categories:
Nicotine polacrilex
Smoking
Dopamine
Nicotine
Bupropion
Mecamylamine

Additional relevant MeSH terms:
Dopamine Uptake Inhibitors
Ganglionic Blockers
Neurotransmitter Uptake Inhibitors
Neurotransmitter Agents
Cholinergic Agonists
Molecular Mechanisms of Pharmacological Action
Cholinergic Antagonists
Nicotinic Agonists
Nicotinic Antagonists
Physiological Effects of Drugs
Psychotropic Drugs
Cardiovascular Agents
Antihypertensive Agents
Cholinergic Agents
Pharmacologic Actions
Habits
Autonomic Agents
Therapeutic Uses
Ganglionic Stimulants
Dopamine Agents
Peripheral Nervous System Agents
Antidepressive Agents, Second-Generation
Central Nervous System Agents
Antidepressive Agents

ClinicalTrials.gov processed this record on August 21, 2008




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