Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation - Full Text View

Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation

This study has been completed.

Sponsored by:	Department of Veterans Affairs
Information provided by:	Department of Veterans Affairs
ClinicalTrials.gov Identifier:	NCT00018148

Purpose

Treatment of smokers with a tricyclic antidepressant, nortriptyline, can reduce tobacco withdrawal symptoms and increases long term cessation rates when combined with transdermal nicotine and a behavioral cessation programs. The study is a placebo-controlled, randomized, parallel group trial in which smokers aged 18-70 will be subject to the combination of oral and patch treatments.

Condition	Intervention	Phase
Smoking	Drug: nortriptyline	Phase II

MedlinePlus related topics:

Quitting Smoking Smoking

Drug Information available for:

Nicotine polacrilex Nicotine tartrate Nortriptyline Nortriptyline hydrochloride

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study

Official Title:	Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation

Further study details as provided by Department of Veterans Affairs:

Study Start Date:	April 1998
Estimated Study Completion Date:	March 2001

Eligibility

Ages Eligible for Study:	18 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Aged 18-70,
smoking > 10 cigarettes per day,
no current major depression,
no concurrent psychiatric medications

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00018148

Locations


United States, Colorado
	VAMC
	Denver, Colorado, United States, 80220

Sponsors and Collaborators

Department of Veterans Affairs

More Information

Study ID Numbers:	ADRD-006-97F
First Received:	July 3, 2001
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00018148
Health Authority:	United States: Federal Government

Keywords provided by Department of Veterans Affairs:

smoking cessation

Study placed in the following topic categories:

Nicotine polacrilex

Smoking

Nicotine

Nortriptyline

Additional relevant MeSH terms:

Neurotransmitter Agents

Neurotransmitter Uptake Inhibitors

Adrenergic Agents

Molecular Mechanisms of Pharmacological Action

Adrenergic Uptake Inhibitors

Physiological Effects of Drugs

Psychotropic Drugs

Pharmacologic Actions

Antidepressive Agents, Tricyclic

Habits

Therapeutic Uses

Central Nervous System Agents

Antidepressive Agents

ClinicalTrials.gov processed this record on December 03, 2008