Language Stimuli Screening in Children

This study has been completed.

First Received: June 2, 2001 Last Updated: March 3, 2008 History of Changes

Sponsored by:	National Institute of Neurological Disorders and Stroke (NINDS)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00016796

Purpose

This study will determine baseline language skills in children 4 to 8 years old. The data will be used to design studies using functional magnetic resonance imaging (fMRI) to identify what areas of the brain in children are involved in understanding language. This information is important for children who require brain surgery to control seizures.

Healthy normal volunteers between the ages of 4 and 8 years who have an IQ of 70 or more; who have no history of neurologic, psychiatric or language disorder; who are performing at or above grade level, and who are native English speakers may be eligible for this study.

Participants will be asked to do the following:

name pictures or read words that appear on a computer screen
listen to stories and answer questions about them
match pictures to a spoken word

The children's responses will be recorded.

Condition
Language Disorder Healthy

Study Type:	Observational
Official Title:	Language Stimuli Screening in Children

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	150
Study Start Date:	May 2001
Estimated Study Completion Date:	March 2005

Detailed Description:

We propose to study normal children to establish baseline data to use to develop novel sets of stimuli for functional imaging paradigms. Tasks using these stimuli will include object naming, sentence comprehension, and single word reading.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

INCLUSION CRITERIA:

Children will be between the ages 4 and 8 are eligible.

EXCLUSION CRITERIA:

Children who meet one of the following criteria are not eligible:

IQ below 70;

History of neurologic or psychiatric disorders;

History of an language disorder;

Performing below grade-level;

Non-native English speaker.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00016796

Locations

United States, Maryland
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Institute of Neurological Disorders and Stroke (NINDS)

More Information

Publications:

Hertz-Pannier L, Gaillard WD, Mott SH, Cuenod CA, Bookheimer SY, Weinstein S, Conry J, Papero PH, Schiff SJ, Le Bihan D, Theodore WH. Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study. Neurology. 1997 Apr;48(4):1003-12.

Devinsky O, Perrine K, Llinas R, Luciano DJ, Dogali M. Anterior temporal language areas in patients with early onset of temporal lobe epilepsy. Ann Neurol. 1993 Nov;34(5):727-32.

Cycowicz YM, Friedman D, Rothstein M, Snodgrass JG. Picture naming by young children: norms for name agreement, familiarity, and visual complexity. J Exp Child Psychol. 1997 May;65(2):171-237.

Study ID Numbers:	010181, 01-N-0181
Study First Received:	June 2, 2001
Last Updated:	March 3, 2008
ClinicalTrials.gov Identifier:	NCT00016796 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Reading
Naming

Study placed in the following topic categories:

Signs and Symptoms
Neurologic Manifestations
Language Disorders

Healthy
Neurobehavioral Manifestations
Communication Disorders

Additional relevant MeSH terms:

Signs and Symptoms
Nervous System Diseases
Neurologic Manifestations

Language Disorders
Neurobehavioral Manifestations
Communication Disorders

ClinicalTrials.gov processed this record on July 02, 2009