Pesticides--Health Fertility and Reproductive Risk - Full Text View

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Pesticides--Health Fertility and Reproductive Risk

This study has been completed.

First Received: April 20, 2001 Last Updated: September 1, 2006 History of Changes

Sponsor:	National Institute of Environmental Health Sciences (NIEHS)
Information provided by:	National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:	NCT00015561

Purpose

This project is designed to establish whether pesticides or other environmental agents have a role in the excess birth defects identified in the Red River Valley of Minnesota. In this human study, laboratory based health parameters will be used to key in health survey data. In vitro data will be developed to mechanistic information. Concordant results among these study features will provide a weight of evidence approach.

Condition
Birth Defects Miscarriages Cancer

Study Type:	Observational
Study Design:	Natural History, Cross-Sectional, Defined Population, Retrospective/Prospective Study

Resource links provided by NLM:

MedlinePlus related topics: Pesticides Pregnancy Loss

U.S. FDA Resources

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment:	1803
Study Start Date:	September 1996
Estimated Study Completion Date:	August 2001

Eligibility

Ages Eligible for Study:	18 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Pesticide applicators and their spouses

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00015561

Locations

United States, Minnesota
University of Minnesota Medical School
Minneapolis, Minnesota, United States, 55414

Sponsors and Collaborators

National Institute of Environmental Health Sciences (NIEHS)

Investigators

Principal Investigator:

Vincent F Garry, MD

University of Minnesota

More Information

Publications:

Lyubimov AV, Garry VF, Carlson RE, Barr DB, Baker SE. Simplified urinary immunoassay for 2,4-D: validation and exposure assessment. J Lab Clin Med. 2000 Aug;136(2):116-24.

Lin N, Garry VF. In vitro studies of cellular and molecular developmental toxicity of adjuvants, herbicides, and fungicides commonly used in Red River Valley, Minnesota. J Toxicol Environ Health A. 2000 Jul 28;60(6):423-39.

Kirkhorn SR, Garry VF. Agricultural lung diseases. Environ Health Perspect. 2000 Aug;108 Suppl 4:705-12. Review.

Garry VF, Burroughs B, Tarone R, Kesner JS. Herbicides and adjuvants: an evolving view. Toxicol Ind Health. 1999 Jan-Mar;15(1-2):159-67.

Schreinemachers DM, Creason JP, Garry VF. Cancer mortality in agricultural regions of Minnesota. Environ Health Perspect. 1999 Mar;107(3):205-11.

Study ID Numbers:	8161-CP-001
Study First Received:	April 20, 2001
Last Updated:	September 1, 2006
ClinicalTrials.gov Identifier:	NCT00015561 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):

population studies
laboratory evaluation
hormone analysis
semen analysis
chromosome studies

Additional relevant MeSH terms:

Pregnancy Complications
Abortion, Spontaneous
Congenital Abnormalities

ClinicalTrials.gov processed this record on November 27, 2009