A primary diagnosis of alcohol dependence within the last three months.
Male or female research participants with a Coccaro Lifetime History of Aggression score of 20 or more.
Reported consumption of seafood no greater than twice per week.
Age of 18 years or older.
Must have been sober for 21-60 days.
Laboratory history and physical exam findings that are without significant abnormalities (significant abnormality would include laboratory deviations that require medical intervention or that indicate a major medical disorder).
EKG and chest X-ray are without clinically significant abnormalities as determined by the physician interpreting the studies.
Educational level and degree of understanding that is sufficient to provide informed consent, sign the consent forms and to allow for clear and intelligent communication between research participant, investigators and staff.
Lifetime history of an axis I psychiatric disorders specifically psychotic, schizophrenic, bipolar affective disorder type I or eating disorders or premenstrual phase dysphoric disorder. Major depression, depressive disorder NOS, panic and other anxiety disorders are not exclusionary. Axis II personality disorders are not exclusionary.
Major medical disorders or major neurological disorders.
Determination by the Principal Investigator that the subject's use of prescription or illicit drugs within the last six months will interfere with the dependent endpoints of the study.
Regular use of prescription medications with psychotropic effects including side effects or medications that modify lipid metabolism, within the last month. Use of NSAIDS, aspirin or Tylenol not more than five times total per week, will be allowed.
Current psychotherapy to reduce aggression or depression.
Extensive use of home remedies, vitamins or nutritional supplements within three months. Use of multi-vitamins one time per day will be allowed.
Pacemaker or other metal implants, which might be a contraindication for a MRI, scan.
Laboratory tests which indicate presence of the HIV.
Allergy to fish or seafood.