Environmental Contaminants and Infant Development

This study is currently recruiting participants.

Verified by National Institute of Environmental Health Sciences (NIEHS), February 2001

First Received: March 30, 2001 Last Updated: June 23, 2005 History of Changes

Sponsor:	National Institute of Environmental Health Sciences (NIEHS)
Collaborators:	Indian and Northern Affairs, Canada Health, Canada Danish Institute for Public Health
Information provided by:	National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:	NCT00013858

Purpose

This study is designed to examine the effects of prenatal exposure to environmental contaminants on cognitive and behavioral development and physical growth in two groups of Inuit infants-one in Northern Quebec; the other in Greenland.

Condition
Mercury Poisoning Lead Poisoning

Study Type:	Observational
Study Design:	Psychosocial, Longitudinal, Defined Population, Prospective Study

Resource links provided by NLM:

MedlinePlus related topics: Lead Poisoning Mercury Poisoning

U.S. FDA Resources

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment:	280
Study Start Date:	January 1997
Estimated Study Completion Date:	December 2002

Detailed Description:

Due to prevailing weather patterns and ocean currents, certain environmental contaminants are transported to the Arctic region. The Inuit are among the most heavily exposed populations on earth due to the prevalence of these contaminants in traditional foods that comprise a large portion of their diet. The contaminants assessed in this study include polychlorinated biphenyls (PCBs), methylmercury, selenium, organochlorine pesticides, and lead. These contaminants are measured in umbilical cord blood samples obtained at birth, milk samples obtained from breast-feeding mothers and, in the case of mercury, hair samples obtained from the mothers. Omega-3 and omega-6 fatty acids are also assessed in these samples to examine the degree to which these nutrients may protect against adverse effects attributable to these contaminants.

Eligibility

Ages Eligible for Study:	up to 1 Day
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

infant born during recruitment period to a mother who is a resident of Povungnituk, Inukjuak, and Kuujjuarapik, Quebec or Nuuk, Greenland

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00013858

Contacts

Contact: Joseph L Jacobson, Ph.D.

313-577-2802

jljacobson@yahoo.com

Locations

Canada, Quebec
Public Health Centre of Quebec	Recruiting
Beauport, Quebec, Canada
Contact: Gina Muckle, Ph.D. 418-666-7000 ext 360 gina.muckle@crchul.ulaval.ca
Principal Investigator: Joseph L Jacobson, Ph.D.

Sponsors and Collaborators

National Institute of Environmental Health Sciences (NIEHS)

Indian and Northern Affairs, Canada

Health, Canada

Danish Institute for Public Health

More Information

Publications:

Dewailly, E., Bruneau, S., Ayotte, P., Liliberte, C., Gingras, S. Belander, D. and Ferron, L. Health status at birth of Inuit newborn prenatally exposed to organochlorines - Chemosphre, 1993, 27: 359-366.

Dewailly E, Ayotte P, Bruneau S, Laliberte C, Muir DC, Norstrom RJ. Inuit exposure to organochlorines through the aquatic food chain in arctic quebec. Environ Health Perspect. 1993 Dec;101(7):618-20.

Jacobson SW, Fein GG, Jacobson JL, Schwartz PM, Dowler JK. The effect of intrauterine PCB exposure on visual recognition memory. Child Dev. 1985 Aug;56(4):853-60.

Jacobson JL, Jacobson SW. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med. 1996 Sep 12;335(11):783-9.

Study ID Numbers:	7902-CP-001
Study First Received:	March 30, 2001
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00013858 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):

methylmercury
PCBs
lead
fish consumption
breast-feeding

Additional relevant MeSH terms:

Mercury Poisoning
Poisoning
Lead Poisoning
Disorders of Environmental Origin

ClinicalTrials.gov processed this record on November 27, 2009