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| Sponsors and Collaborators: |
National Institute of Environmental Health Sciences (NIEHS) Indian and Northern Affairs, Canada Health, Canada Danish Institute for Public Health |
| Information provided by: | National Institute of Environmental Health Sciences (NIEHS) |
| ClinicalTrials.gov Identifier: | NCT00013858 |
Purpose
This study is designed to examine the effects of prenatal exposure to environmental contaminants on cognitive and behavioral development and physical growth in two groups of Inuit infants-one in Northern Quebec; the other in Greenland.
| Condition |
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Mercury Poisoning Lead Poisoning |
| MedlinePlus related topics: | Lead Poisoning Mercury Poisoning |
| Study Type: | Observational |
| Study Design: | Psychosocial, Longitudinal, Defined Population, Prospective Study |
| Estimated Enrollment: | 280 |
| Study Start Date: | January 1997 |
| Estimated Study Completion Date: | December 2002 |
Due to prevailing weather patterns and ocean currents, certain environmental contaminants are transported to the Arctic region. The Inuit are among the most heavily exposed populations on earth due to the prevalence of these contaminants in traditional foods that comprise a large portion of their diet. The contaminants assessed in this study include polychlorinated biphenyls (PCBs), methylmercury, selenium, organochlorine pesticides, and lead. These contaminants are measured in umbilical cord blood samples obtained at birth, milk samples obtained from breast-feeding mothers and, in the case of mercury, hair samples obtained from the mothers. Omega-3 and omega-6 fatty acids are also assessed in these samples to examine the degree to which these nutrients may protect against adverse effects attributable to these contaminants.
Eligibility
| Ages Eligible for Study: | up to 1 Day |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
infant born during recruitment period to a mother who is a resident of Povungnituk, Inukjuak, and Kuujjuarapik, Quebec or Nuuk, Greenland
Contacts and Locations| Contact: Joseph L Jacobson, Ph.D. | 313-577-2802 | jljacobson@yahoo.com |
| Canada, Quebec | |||||
| Public Health Centre of Quebec | Recruiting | ||||
| Beauport, Quebec, Canada | |||||
| Contact: Gina Muckle, Ph.D. 418-666-7000 ext 360 gina.muckle@crchul.ulaval.ca | |||||
| Principal Investigator: Joseph L Jacobson, Ph.D. | |||||
| National Institute of Environmental Health Sciences (NIEHS) |
| Indian and Northern Affairs, Canada |
| Health, Canada |
| Danish Institute for Public Health |
More Information
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Dewailly, E., Bruneau, S., Ayotte, P., Liliberte, C., Gingras, S. Belander, D. and Ferron, L. Health status at birth of Inuit newborn prenatally exposed to organochlorines - Chemosphre, 1993, 27: 359-366.
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Dewailly E, Ayotte P, Bruneau S, Laliberte C, Muir DC, Norstrom RJ. Inuit exposure to organochlorines through the aquatic food chain in arctic quebec. Environ Health Perspect. 1993 Dec;101(7):618-20.
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Jacobson SW, Fein GG, Jacobson JL, Schwartz PM, Dowler JK. The effect of intrauterine PCB exposure on visual recognition memory. Child Dev. 1985 Aug;56(4):853-60.
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Jacobson JL, Jacobson SW. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med. 1996 Sep 12;335(11):783-9.
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| Study ID Numbers: | 7902-CP-001 |
| First Received: | March 30, 2001 |
| Last Updated: | June 23, 2005 |
| ClinicalTrials.gov Identifier: | NCT00013858 |
| Health Authority: | United States: Federal Government |
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