Genetic Analysis of Familial Brain Aneurysms - Full Text View

Purpose

This study will investigate cerebral (brain) aneurysms and their possible inheritance patterns in families. It will try to determine how often brain aneurysms occur in families in which more than one member has had an aneurysm and to find the gene or genes that contribute to their development.

People in families in which more than one family member had a cerebral aneurysm are eligible for this 1-day study. They will undergo the following procedures:

Blood will be drawn (no more than 3 to 4 tablespoons) for research to identify genes that contribute to the development of brain aneurysms.
A magnetic resonance angiograph (MRA) scan will be done to examine a specific brain area where aneurysms typically occur. Magnetic resonance imaging uses a strong magnetic field and radio waves to produce images of the brain and detect abnormalities.

If a more detailed picture of the brain is needed than can be obtained with MRA, a more specific MRA scan will be done using a contrast dye to enhance the images.

Patients may be invited to participate in related NIH research studies.

Condition

Intracranial Aneurysm

MedlinePlus related topics:

Aneurysms

U.S. FDA Resources

Study Type:	Observational

Official Title:	Linkage Analysis of Familial Intracranial Aneurysms

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	300
Study Start Date:	February 2001
Estimated Study Completion Date:	March 2002

Detailed Description:

This study is designed to explore the genetics of familial cerebral aneurysms. Families in which more than one person has had a known cerebral aneurysm will be studied. Family histories will be obtained and participants identified who are willing to come to the NIH Clinical Center for an MRAngiograph and venipuncture. DNA will be isolated and linkage studies undertaken to identify loci involved in the etiology of familial cerebral aneurysms, using standard linkage approaches.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

INCLUSION CRITERIA:

Participants and their relatives that are affected or at a higher risk for cerebral aneurysms will be enrolled in this protocol.

EXCLUSION CRITERIA:

For the MR Angiograph portion of the study, any participant that is not able to sign the Clinical Center consent form due to metal implants, pregnancy, claustrophobia, or an allergy to gadolinium as a contrast will be excluded from the imaging part of the study.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00011856

Locations


United States, Maryland
	National Human Genome Research Institute (NHGRI)
	Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Human Genome Research Institute (NHGRI)

More Information

Study ID Numbers:	010101, 01-HG-0101
First Received:	March 1, 2001
Last Updated:	March 3, 2008
ClinicalTrials.gov Identifier:	NCT00011856
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Intracranial Aneurysms

Cerebral

Loci

Susceptibility Genes

Cerebral Aneurysm

Familial Cerebral Aneurysm

Genetics

Study placed in the following topic categories:

Intracranial Aneurysm

Disease Susceptibility

Aneurysm

Vascular Diseases

Central Nervous System Diseases

Genetic Predisposition to Disease

Brain Diseases

Cerebrovascular Disorders

Intracranial Arterial Diseases

Cerebral aneurysm

Additional relevant MeSH terms:

Nervous System Diseases

Cardiovascular Diseases

ClinicalTrials.gov processed this record on December 03, 2008

Sponsored by:	National Human Genome Research Institute (NHGRI)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00011856