DISEASE CHARACTERISTICS:

• Histologically proven metastatic breast cancer

  • HER2/neu-positive (overexpressing) tumor tissue
• Failed prior trastuzumab (Herceptin) therapy with or without chemotherapy
• Resected stage IV disease allowed if evidence of disease

• Bidimensionally measurable or evaluable disease

  • No lesions in previously irradiated field except nonbone lesions progressive after radiotherapy
  • No pleural effusions
  • No blastic or mixed bony metastases
  • No palpable abdominal masses
• No leptomeningeal disease

• Brain metastases allowed if:

  • No concurrent use of steroids
  • At least 3 months since prior brain irradiation
  • No evidence of progression of metastases

• Hormone receptor status:

  • Not specified

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Sex:

• Female

Menopausal status:

• Not specified

Performance status:

• Karnofsky 70-100%

Life expectancy:

• At least 3 months

Hematopoietic:

• Granulocyte count at least 1,500/mm^3
• Hemoglobin at least 8.0 g/dL
• Platelet count at least 100,000/mm^3

Hepatic:

• AST/ALT no greater than 2 times upper limit of normal (ULN)
• Bilirubin no greater than 1.5 times ULN

Renal:

• Creatinine no greater than 1.5 mg/dL

Cardiovascular:

• LVEF at least 50%

Other:

• Not pregnant
• Negative pregnancy test
• Fertile patients must use effective barrier contraception
• No other prior malignancy within the past 5 years except adequately treated carcinoma in situ of the cervix or nonmelanoma skin cancer
• No other serious medical illness
• No severe infection
• No severe malnutrition
• No prior allergic reactions to sulfonamides or celecoxib

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• See Disease Characteristics
• Prior trastuzumab (Herceptin) for breast cancer allowed, either as adjuvant/neoadjuvant or for metastatic disease

Chemotherapy:

• See Disease Characteristics
• At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered
• Prior cytotoxic therapy for breast cancer allowed, either as adjuvant/neoadjuvant or for metastatic disease

Endocrine therapy:

• See Disease Characteristics
• At least 3 weeks since prior hormonal therapy
• Prior exogenous hormonal therapy for stage IV disease and/or as adjuvant therapy allowed

Radiotherapy:

• See Disease Characteristics
• At least 4 weeks since prior radiotherapy and recovered
• Prior localized radiotherapy allowed if no influence on the signal measurable lesion
• Concurrent localized radiotherapy allowed if no influence on the signal measurable lesion

Surgery:

• See Disease Characteristics
• At least 3 weeks since prior major surgery and recovered
• At least 2 weeks since prior minor surgery and recovered