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Study of Arthritis and Related Conditions
This study is currently recruiting participants.
Verified by National Institutes of Health Clinical Center (CC), May 2009
First Received: October 4, 2000   Last Updated: June 10, 2009   History of Changes
Sponsored by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by: National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier: NCT00006333
  Purpose

This research protocol will recruit patients with arthritis and related conditions for the purpose of screening patients for treatment protocols, and evaluating the natural history of arthritis and related conditions. Patients will be evaluated clinically, radiographically and serologically, and standardized data will be uniformly collected on all patients. Additional imaging using sensitive MRI methods will be obtained in some patients. The collected blood and tissue will be utilized for laboratory studies to continue research on the pathogenic mechanisms of rheumatoid arthritis and related autoimmune joint diseases. Data from the history and physical examination as well as several disability questionnaires in the adult and pediatric population will be used to phenotypically characterize these patients and assess outcome and functional status. Any medical care recommended or provided to the patients will be consistent with routine standards of practice and provided in consultation with the patient's referring physician.


Condition
Arthritis
Synovitis

Study Type: Observational
Official Title: Studies of the Pathogenesis and Natural History of Arthritis and Related Conditions

Resource links provided by NLM:

MedlinePlus related topics: Rheumatoid Arthritis
U.S. FDA Resources

Further study details as provided by National Institutes of Health Clinical Center (CC):

Study Start Date: September 2000
Detailed Description:

This research protocol will recruit patients with arthritis and related conditions for the purpose of screening patients for treatment protocols, and evaluating the natural history of arthritis and related conditions. Patients will be evaluated clinically, radiographically and serologically, and standardized data will be uniformly collected on all patients. Additional imaging using sensitive MRI methods will be obtained in some patients. The collected blood and tissue will be utilized for laboratory studies to continue research on the pathogenic mechanisms of rheumatoid arthritis and related autoimmune joint diseases. Data from the history and physical examination as well as several disability questionnaires in the adult and pediatric population will be used to phenotypically characterize these patients and assess outcome and functional status. Any medical care recommended or provided to the patients will be consistent with routine standards of practice and provided in consultation with the patient's referring physician.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria
  • INCLUSION CRITERIA:

No age limits.

History of inflammatory synovitis of at least one or more swollen joints.

Patient's ability and willingness to give informed consent or in the pediatric patients, the parent's willingness to give informed consent and the patient's willingness to assent to the protocol whenever possible.

EXCLUSION CRITERIA:

None if patients fulfill inclusion criteria.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00006333

Contacts
Contact: Patient Recruitment and Public Liaison Office (800) 411-1222 prpl@mail.cc.nih.gov
Contact: TTY 1-866-411-1010

Locations
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
  More Information

Additional Information:
NIH Clinical Center Detailed Web Page  This link exits the ClinicalTrials.gov site

Publications:
Lin JP, Cash JM, Doyle SZ, Peden S, Kanik K, Amos CI, Bale SJ, Wilder RL. Familial clustering of rheumatoid arthritis with other autoimmune diseases. Hum Genet. 1998 Oct;103(4):475-82.
Case JP, Lafyatis R, Remmers EF, Kumkumian GK, Wilder RL. Transin/stromelysin expression in rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes. Am J Pathol. 1989 Dec;135(6):1055-64.
Glass DN, Giannini EH. Juvenile rheumatoid arthritis as a complex genetic trait. Arthritis Rheum. 1999 Nov;42(11):2261-8. Review. No abstract available.

Study ID Numbers: 000222, 00-AR-0222
Study First Received: October 4, 2000
Last Updated: June 10, 2009
ClinicalTrials.gov Identifier: NCT00006333     History of Changes
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Rheumatoid Arthritis
Inflammation
Synovitis
Genetics
Synovial Biopsy
 Arthritis
Juvenile Rheumatoid Arthritis
Rheumatoid Arthritis
Juvenile Rheumatoid Arthritis
JRA

Study placed in the following topic categories:
Arthritis, Juvenile Rheumatoid
Musculoskeletal Diseases
Joint Diseases
Arthritis
 Arthritis, Rheumatoid
Synovitis
Inflammation

Additional relevant MeSH terms:
Musculoskeletal Diseases
Joint Diseases
Arthritis
Synovitis

ClinicalTrials.gov processed this record on July 02, 2009



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