DISEASE CHARACTERISTICS:

• Diagnosis of chronic lymphocytic leukemia (CLL) evidenced by monoclonal population of mature CD5+, CD19+, CD23+, and B cells
• Relapsed after prior treatment for CLL

• Active disease with 1 or more of the following characteristics:

  • At least 10% weight loss within the past 6 months
  • Fever greater than 100.5 degrees F for at least 2 weeks without evidence of infection
  • Night sweats without evidence of infection
  • Evidence of progressive marrow failure with anemia (hemoglobin less than 11 g/dL) and/or thrombocytopenia (platelet count less than 100,000/mm^3) (i.e., any stage III or IV disease)
  • Autoimmune anemia and/or thrombocytopenia poorly responsive to corticosteroid therapy
  • Massive or progressive splenomegaly (i.e., greater than 6 cm below the left costal margin or more than 50% increase over 2 months)
  • Progressive lymphadenopathy (i.e., more than 50% increase over 2 months)
  • Progressive lymphocytosis (not due to corticosteroids) with an increase of more than 50% over a 2-month period or an anticipated doubling time of less than 6 months
  • Marked hypogammaglobulinemia or the development of a monoclonal protein in the absence of any of the above criteria for active disease are not considered evidence of active disease

• Measurable disease

  • Absolute lymphocyte count greater than 5,000/mm^3
• No bulky lymph node disease greater than 10 cm in at least 1 dimension except splenomegaly

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• ECOG 0-2

Life expectancy:

• Not specified

Hematopoietic:

• See Disease Characteristics
• Absolute neutrophil count at least 500/mm^3
• Platelet count at least 20,000/mm^3 (in absence of sargramostim [GM-CSF])
• Hemoglobin at least 8 g/dL

Hepatic:

• Bilirubin no greater than 2.5 times upper limit of normal (ULN)
• AST no greater than 2.5 times ULN

Renal:

• Creatinine no greater than 1.5 mg/dL OR
• Creatinine clearance at least 60 mL/min

Other:

• No other active malignancy
• No peripheral neuropathy (sensory) grade 2 or greater
• No active infection
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use 1 highly effective method of contraception AND 1 additional effective method of contraception for at least 4 weeks before, during, and for 4 weeks after study completion

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• No prior allogeneic bone marrow transplantation
• At least 10 days since prior filgrastim (G-CSF) or GM-CSF

Chemotherapy:

• No more than 3 prior chemotherapy regimens
• At least 30 days since prior chemotherapy

Endocrine therapy:

• See Disease Characteristics
• No concurrent corticosteroids except for adrenal insufficiency

Radiotherapy:

• Not specified

Surgery:

• Not specified