Diagnostic Pilot Study of Dual Energy Absorptiometry in the Detection of Osteopenia or Osteoporosis in Patients With Thalassemia Major - Full Text View

Diagnostic Pilot Study of Dual Energy Absorptiometry in the Detection of Osteopenia or Osteoporosis in Patients With Thalassemia Major

This study has been completed.

Sponsors and Collaborators:	National Center for Research Resources (NCRR) Children's Hospital of Philadelphia
Information provided by:	Office of Rare Diseases (ORD)
ClinicalTrials.gov Identifier:	NCT00006138

Purpose

OBJECTIVES:

I. Determine the frequency and severity of osteopenia and osteoporosis in patients with thalassemia major who undergo dual energy x-ray absorptiometry, and correlate these findings with other relevant endocrinologic measurements.

Condition

Osteoporosis
Thalassemia Major
Osteopenia

Genetics Home Reference related topics:

beta thalassemia

MedlinePlus related topics:

Osteoporosis Thalassemia

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening

Further study details as provided by Office of Rare Diseases (ORD):

Estimated Enrollment:	35
Study Start Date:	June 1998
Estimated Study Completion Date:	August 2000

Detailed Description:

PROTOCOL OUTLINE:

Patients undergo dual energy x-ray absorptiometry for bone density measurements, height (sitting and standing) and weight measurements, comprehensive endocrinologic examination, and assessment of the severity of iron overload at baseline, and then at years 1 and 2.

Eligibility

Ages Eligible for Study:	6 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Diagnosis of thalassemia major with iron overload
Not pregnant
Negative pregnancy test

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00006138

Sponsors and Collaborators

National Center for Research Resources (NCRR)

Children's Hospital of Philadelphia

Investigators


Study Chair:	Alan Richard Cohen	Children's Hospital of Philadelphia

More Information

Study ID Numbers:	199/15314, CHP-IRB-1998-6-1502, CHP-GCRC-1655
First Received:	August 3, 2000
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00006138
Health Authority:	United States: Federal Government

Keywords provided by Office of Rare Diseases (ORD):

disease-related problem/condition

genetic diseases and dysmorphic syndromes

hematologic disorders

osteoporosis

rare disease

thalassemia major

Study placed in the following topic categories:

Hematologic Diseases

Beta-thalassemia

Rare Diseases

Anemia

Osteoporosis

Anemia, Hemolytic

Bone Diseases, Metabolic

Thalassemia

Bone Diseases

Anemia, Hemolytic, Congenital

Thalassemia minor

Genetic Diseases, Inborn

Musculoskeletal Diseases

Beta-Thalassemia

Hemoglobinopathies

Hemoglobinopathy

ClinicalTrials.gov processed this record on October 10, 2008