OBJECTIVES: I. Determine the rate of complete or major cytogenetic response to arsenic trioxide as demonstrated by a decrease in the percentage of Philadelphia chromosome positive (or breakpoint cluster region bcr positive) cells in the bone marrow in patients with interferon alfa refractory or intolerant chronic phase chronic myelogenous leukemia. II. Determine the rate and duration of complete hematological response to this treatment in these patients. III. Determine the duration of complete and major cytogenetic response to this treatment in these patients. IV. Determine the pattern of clinical adverse experience and improvement in symptomatic parameters with this treatment in these patients. V. Determine the time to accelerated disease or blast crisis and overall survival in these patients after receiving this treatment. VI. Determine the effects of this treatment on cytokines, apoptosis, and angiogenesis in these patients.

OUTLINE: Patients receive arsenic trioxide IV over 2 hours either daily for 15 consecutive days or 5 days on, 2 days off for a total of 15 doses. Treatment repeats every 2-5 weeks after the previous course for a maximum of 12 courses in the absence of disease progression or unacceptable toxicity. Patients achieving complete remission are followed every month for 3 months, every 2 months for 6 months, every 3-4 months for 1 year, and then every 6 months thereafter. All other patients are followed every 3 months for 1 year and then annually thereafter.

PROJECTED ACCRUAL: A total of 17-53 patients will be accrued for this study within 2.5 years.

DISEASE CHARACTERISTICS: Diagnosis of Philadelphia (Ph) chromosome positive (or breakpoint cluster region bcr positive) chronic myelogenous leukemia in chronic phase Ineligible for or refused allogeneic bone marrow transplantation Interferon alfa refractory or intolerant as defined by the following: Refractory: Failure to achieve a complete hematologic response lasting for at least 1 month after prior therapy with interferon alfa based regimen for at least 3 months 65% or more Ph positive chromosomes in bone marrow after one year of interferon alfa based therapy At least a 30% increase in Ph positive chromosomes in bone marrow in samples taken at least one month apart OR An increase of at least 65% in Ph positive chromosomes in bone marrow Intolerant: Grade 3 or greater nonhematologic toxicity Autoimmune phenomenon at any grade No accelerated phase or blastic phase disease as defined by the following: Greater than 15% blasts or basophils in the peripheral blood or bone marrow Greater than 30% blasts plus promyelocytes in the peripheral blood or bone marrow Documented extramedullary blastic disease outside liver or spleen Platelet count less than 100,000/mm3 unrelated to therapy Clonal evolution (additional chromosomal abnormalities other than Ph chromosome) as solitary feature is not considered accelerated disease No known brain metastases or CNS disease

PATIENT CHARACTERISTICS: Age: 12 and over Performance status: Zubrod 0-2 Life expectancy: At least 2 years Hematopoietic: See Disease Characteristics Hepatic: Unless due to direct disease infiltration of the liver: ALT and AST no greater than 2.5 times upper limit of normal (ULN) Bilirubin no greater than 1.5 times ULN (unless due to Gilbert's disease) No hepatic disease that would preclude study Renal: Creatinine no greater than 1.5 times ULN Creatinine clearance at least 60 mL/min Cardiovascular: No history of New York Heart Association grade III or IV cardiac disease No cardiovascular disease that would preclude study No unstable angina pectoris or cardiac arrhythmia that would shorten life expectancy Other: No history of grand mal seizures other than infantile febrile seizures No active secondary malignancy or other uncontrolled concurrent medical problem that would shorten life expectancy No neurologic, endocrine, or other major systemic disease that would preclude study No active infection uncontrolled by oral or IV antibiotics No history of hypersensitivity to the study drug or drugs with similar chemical structure No mental condition that would preclude study Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY: Biologic therapy: See Disease Characteristics No concurrent bone marrow or peripheral blood stem cell transplantation Chemotherapy: At least 14 days since prior chemotherapy (48 hours for hydroxyurea and 6 weeks for busulfan) and recovered (unless evidence of rapidly progressive disease) No other concurrent cytotoxic chemotherapy No prior arsenic trioxide Endocrine therapy: No concurrent steroids for the treatment of neoplasms (except for new adrenal failures) No concurrent hormones for the treatment of neoplasms (except for nondisease related conditions) Radiotherapy: At least 14 days since prior radiotherapy No concurrent radiotherapy Surgery: Not specified Other: At least 14 days since other prior investigational agent No other concurrent investigational or antileukemic agents