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Diagnosis/Pathophysiology of Glucocorticoid Remediable Aldosteronism Hypertension

This study has been completed.

Sponsored by: National Heart, Lung, and Blood Institute (NHLBI)
Information provided by: National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier: NCT00005394
  Purpose

To identify and study a large cohort of glucocorticoid remediable aldosteronism (GRA) patients.


Condition
Cardiovascular Diseases
Hypertension
Heart Diseases

MedlinePlus related topics:   Heart Diseases    High Blood Pressure   

U.S. FDA Resources

Study Type:   Observational
Study Design:   Natural History

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date:   August 1995
Estimated Study Completion Date:   July 2000

Detailed Description:

DESIGN NARRATIVE:

The spectrum of the severity and the natural history of the disorder was characterized. Modifying environmental and genetic factors important in regulation of blood pressure were determined. Also, renal physiology was studied in GRA patients to determine how these patients escaped hypokalemia in spite of mineralocorticoid excess. There were four specific aims including: 1) to determine the natural history and prevalence of GRA in various hypertensive populations, 2) to characterize the magnitude of effect imparted on blood pressure by inheritance of GRA and the sources of variation in phenotype expression of the hypertension, 3) to investigate the renal and hormonal mechanisms regulating potassium conservation and loss in GRA, and 4) to characterize the disequilibrium of GRA with Irish and Scottish descent and specific alleles of the aldosterone synthase gene.

  Eligibility
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Criteria

No eligibility criteria

  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00005394

Sponsors and Collaborators

Investigators
Investigator:     Richard Lifton     Yale University    
  More Information


Publications:

Study ID Numbers:   4300
First Received:   May 25, 2000
Last Updated:   June 23, 2005
ClinicalTrials.gov Identifier:   NCT00005394
Health Authority:   United States: Federal Government

Study placed in the following topic categories:
Heart Diseases
Vascular Diseases
Hyperaldosteronism
Hypertension

Additional relevant MeSH terms:
Cardiovascular Diseases

ClinicalTrials.gov processed this record on December 03, 2008




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