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| Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
| Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
| ClinicalTrials.gov Identifier: | NCT00005309 |
Purpose
To examine mechanisms of individual differences in the progression of HIV infection in hemophiliacs.
| Condition |
|
Acquired Immunodeficiency Syndrome HIV Infections Blood Disease Hemophilia A Hepatitis, Viral, Human Blood Transfusion Cytomegalovirus Infections |
| Genetics Home Reference related topics: | hemophilia |
| MedlinePlus related topics: | AIDS Blood Transfusion and Donation Cytomegalovirus Infections Hemophilia Hepatitis |
| Study Type: | Observational |
| Study Design: | Natural History |
| Study Start Date: | July 1990 |
| Estimated Study Completion Date: | March 1995 |
BACKGROUND:
In the late 1980s, hemophiliacs were transfused with a variety of blood products, including large amounts of cryoprecipitate. In comparison to other cohorts, hemophiliacs are CMV(-), resulting in a comparison group for the study of this virus as a potential cofactor. In contrast, non A, non-B hepatitis is common in comparison to other cohorts, and preliminary data prior to 1990 suggested that this chronic disease predisposes to more rapid progression of HIV infection.
DESIGN NARRATIVE:
Disease-free survival rates were determined in HIV-infected hemophiliacs. The effects of co-factors such as intensive transfusion, concomitant cytomegalovirus or chronic NANB hepatitis infection were ascertained. Host-virus interaction was assessed through the use of plasma cultures, specific antibody titers, and markers of immune changes detected by flow cytometry and immune function assays. The immunology of asymptomatic stable infection was investigated. The safety of volunteer donor blood products was determined in seronegative patients exposed to over 50,000 donors yearly and the risk of sexual transmission of HIV to spouses of seropositive patients was monitored.
Eligibility
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | No |
No eligibility criteria
Contacts and Locations More Information
| Study ID Numbers: | 3012 |
| First Received: | May 25, 2000 |
| Last Updated: | June 23, 2005 |
| ClinicalTrials.gov Identifier: | NCT00005309 |
| Health Authority: | United States: Federal Government |
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