Genetic and Environmental Determinants of Hypertension

This study has been completed.
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00005149
First received: May 25, 2000
Last updated: June 23, 2005
Last verified: May 2000
  Purpose

To determine the pathophysiology of different types of essential hypertension by identifying the discrete effects of major genes and environmental variables as determinants of the subtypes of essential hypertension.


Condition
Cardiovascular Diseases
Heart Diseases
Hypertension

Study Type: Observational

Resource links provided by NLM:


Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: February 1980
Estimated Study Completion Date: November 1992
Detailed Description:

BACKGROUND:

Essential hypertension is believed to be a heterogeneous group of disorders, the subtypes of which could be related to sodium sensitivity, obesity, diabetes, calcium intake and metabolism, the renin-angiotensin balance, or membrane cation transport. Essential hypertension aggregates in families. The syndromes leading to hypertension may involve shared genes, shared environmental factors, or both.

DESIGN NARRATIVE:

In 1980 a series of biochemical and physiological tests were initiated in the 2,548 persons in 98 extended pedigrees in Utah. Most of the subjects were obtained from three major pedigree types: stroke cluster pedigrees; coronary heart disease cluster pedigrees; and pedigrees of Utah Hypertension Detection and Follow-up Program high blood pressure probands. Data were collected on personal history, medical family history and genealogy, anthropometrics, standard and 32-lead electro- cardiograms, multiple blood pressure measurements during sitting, standing, lying, tilting, isometric hand grip exercise, bicycle exercise, venipuncture and mental arithmetic. Cation tests included sodium-lithium countertransport, lithium-potassium co-transport, intracellular sodium, potassium, magnesium, sodium-potassium ATP-ase pump activity and binding sites and plasma levels of sodium, potassium, magnesium, ionized calcium and digoxin-like pump inhibitor. Information was also collected on stress, exercise, plasma renin activity, and urinary kallikrein. Statistical and pedigree analysis were conducted.

The same tests were also performed on 600 new population-based hypertensive subjects on drug therapy and again four months after interruption of drug therapy. Tests were conduced for specific subtypes of high blood pressure among the 600 subjects using individual variables and multivariate combinations of variables. Three hundred nuclear families were screened to test for familiality of subtype indicators and to identify those high blood pressure subtype indicator variables needing detailed pedigree analysis.

One thousand sequentially-sampled persons were studied for major genes, DNA probe linkage, and gene-environment interactions as determinants of specific types of hypertension.

  Eligibility

Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

No eligibility criteria

  Contacts and Locations
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No Contacts or Locations Provided
  More Information

Publications:
Williams RR, Hunt SC, Dadone MM, Hasstedt S, Smith JB, Ash KO, Kuida H: Preliminary Analysis of Sodium-Lithium Countertransport and Blood Pressure in Utah Pedigrees. In: Topics In Pathophysiology Of Hypertension (Villarreal H, Sambhi MP, Eds). Boston: Martinus Nijhoff Publishers. pp 112-135, 1984
Williams RR, Dadone M, Hunt SC, Jorde LB, Hopkins PN, Smith JB, Ash KO, Kuida H: The Genetic Epidemiology of Hypertension: A Review of Past Studies and Current Results for 948 Persons in 48 Utah Pedigrees. In: Genetic Epidemiology of Coronary Heart Disease: Past, Present, and Future (Rao DC, Elston RC, Kuller LH, Feinleib M, Carter C, Havlik R, Eds). New York: Alan R, Liss, Inc., pp 419-444, 1984
Williams RR, Hunt SC, Dadone MM, Smith JB, Ash KO, Kuida K: Cation Flux and Other Possible Biological Markers of Genetically Predisposed Hypertension. In: Children's Blood Pressure, Report of the Eighty- Eighth Ross Conference on Pediatric Research (Filer LJ and Lauer RM, Eds). Columbus, Ohio: Ross Laboratories, pp 100-123, 1984

ClinicalTrials.gov Identifier: NCT00005149     History of Changes
Other Study ID Numbers: 1020
Study First Received: May 25, 2000
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Hypertension
Vascular Diseases

ClinicalTrials.gov processed this record on September 14, 2014