Study of New Magnetic Resonance Imaging Methods of the Brain

This study is currently recruiting participants. (see Contacts and Locations)
Verified November 2013 by National Institutes of Health Clinical Center (CC)
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00004577
First received: February 18, 2000
Last updated: September 16, 2014
Last verified: November 2013
  Purpose

The purpose of this investigation is to develop improved magnetic resonance imaging (MRI) techniques and hardware for studying brain function. MRI is a diagnostic tool that provides information about brain chemistry and physiology. This study will evaluate new MRI methods for monitoring blood flow to regions of the brain in response to simple tasks. The MRI machine used in this study is more powerful than those in most hospitals, permitting a higher visual resolution.

Normal healthy volunteers over 18 years old may be eligible for this study. Candidates will be screened with a medical history and questionnaire, and a neurological examination. Study participants will have a yearly MRI scan. For this procedure, the subject lies on a stretcher that is moved into a donut-shaped machine with a strong magnetic field. A lightweight circular or rectangular coil a device that improves the quality of the images may be placed on the head. The scan time varies from 20 minutes to 3 hours; most scans last between 45 and 90 minutes. During the scan, the subject may perform simple tasks, such as listening to tapes, tapping a finger, moving a hand, watching a screen, or smelling a fragrance. More complex tasks may require thinking about tones or pictures and responding to them by pressing buttons.

Information from this study will be used to develop better imaging methods that will, in turn, permit a greater understanding of normal and abnormal brain behaviors.


Condition
Healthy

Study Type: Observational
Official Title: Characterization of Brain Morphology and Activity Using Functional and Anatomical MRI Contrast

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 650
Study Start Date: February 2000
Detailed Description:

The goal of this protocol is to improve the spatial resolution in MRI studies of the changes in hemodynamics that occur in the central nervous system (CNS) in healthy controls in response to sensory, motor, or cognitive stimulation.

CNS functional changes will be characterized by measuring blood flow, blood transit time, and blood oxygenation. These studies are required in order to develop and implement new imaging techniques for research and clinical applications on the 3.0T, and 7.0T MRI.

Techniques will be developed for anatomical and spectroscopic MRI that can take advantage of 7T field strength, extending parallel imaging strategies to 7T to realize the full gain in sensitivity. The aim is to obtain very high resolution anatomical MRI, high temporal and spatial resolution blood oxygenation (BOLD) and perfusion images, and spectroscopic studies of metabolites of the brain. All of these developments will be performed on normal, healthy volunteers.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria
  • INCLUSION CRITERIA:

Any neurologically and psychiatrically normal, male or female, healthy volunteer over 18 years old. Subjects must be capable of understanding the procedures and requirements of this study. Subjects must be willing to sign an informed consent document.

EXCLUSION CRITERIA:

A subject will be excluded if he/she has a contraindication to MR scanning such as the following: pregnancy, aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant; ocular foreign body (e.g. metal shavings), insulin pump or any pre-existing eye conditions. Subjects who underwent brain surgery, who have a central nervous system illness, neurological lesion, a psychiatric history or recurrent migraines that require medication will also be excluded from this study. Uncontrolled medical problems, such as diabetes mellitus, hypertension, pulmonary or airway disease, heart failure, coronary artery disease. The contraindications to MRI at both 3.0 T and 7T are almost identical - except the 7T also excludes ferromagnetic dental bridges or crowns.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00004577

Contacts
Contact: Susan Guttman (301) 451-9912 fultons@mail.nih.gov
Contact: Alan P. Koretsky, Ph.D. (301) 402-9659 koretskya@ninds.nih.gov

Locations
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)    800-411-1222 ext TTY8664111010    prpl@mail.cc.nih.gov   
Sponsors and Collaborators
Investigators
Principal Investigator: Alan P. Koretsky, Ph.D. National Institute of Neurological Disorders and Stroke (NINDS)
  More Information

Additional Information:
Publications:
ClinicalTrials.gov Identifier: NCT00004577     History of Changes
Other Study ID Numbers: 000082, 00-N-0082
Study First Received: February 18, 2000
Last Updated: September 16, 2014
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
BOLD Effect
Cerebral Blood Flow
Cerebral Blood Volume
Functional Imaging
Magnetic Resonance Imaging
Technical Developments

ClinicalTrials.gov processed this record on October 20, 2014