Study of New Magnetic Resonance Imaging Methods of the Brain
The purpose of this investigation is to develop improved magnetic resonance imaging (MRI) techniques and hardware for studying brain function. MRI is a diagnostic tool that provides information about brain chemistry and physiology. This study will evaluate new MRI methods for monitoring blood flow to regions of the brain in response to simple tasks. The MRI machine used in this study is more powerful than those in most hospitals, permitting a higher visual resolution.
Normal healthy volunteers over 18 years old may be eligible for this study. Candidates will be screened with a medical history and questionnaire, and a neurological examination. Study participants will have a yearly MRI scan. For this procedure, the subject lies on a stretcher that is moved into a donut-shaped machine with a strong magnetic field. A lightweight circular or rectangular coil-a device that improves the quality of the images-may be placed on the head. The scan time varies from 20 minutes to 3 hours; most scans last between 45 and 90 minutes. During the scan, the subject may perform simple tasks, such as listening to tapes, tapping a finger, moving a hand, watching a screen, or smelling a fragrance. More complex tasks may require thinking about tones or pictures and responding to them by pressing buttons.
Information from this study will be used to develop better imaging methods that will, in turn, permit a greater understanding of normal and abnormal brain behaviors.
|Official Title:||Characterization of Brain Morphology and Activity Using Functional and Anatomical MRI Contrast|
|Study Start Date:||February 2000|
The goal of this protocol is to improve the spatial resolution in MRI studies of the changes in hemodynamics that occur in the central nervous system (CNS) in healthy controls in response to sensory, motor, or cognitive stimulation.
CNS functional changes will be characterized by measuring blood flow, blood transit time, and blood oxygenation. These studies are required in order to develop and implement new imaging techniques for research and clinical applications on the 1.5T, 3.0T, and the 7.0T.
Techniques will be developed for anatomical and spectroscopic MRI that can take advantage of 7T field strength, extending parallel imaging strategies to 7T to realize the full gain in sensitivity. The aim is to obtain very high resolution anatomical MRI, high temporal and spatial resolution blood oxygenation (BOLD) and perfusion images, and spectroscopic studies of metabolites of the brain. All of these developments will be performed on normal, healthy volunteers.
|Contact: Susan Guttman||(301) firstname.lastname@example.org|
|Contact: Alan P. Koretsky, Ph.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 firstname.lastname@example.org|
|Principal Investigator:||Alan P. Koretsky, Ph.D.||National Institute of Neurological Disorders and Stroke (NINDS)|