Inclusion Criteria:

• Current diagnosis of major depression for a 2-week duration following discontinuation of drinking or prior to study.
• Meets criteria for alcohol dependence.
• Drank a minimum of 48 standard alcoholic drinks prior to treatment (average of 12 drinks/week) on 40% of the 30 days before treatment.
• Able to maintain abstinence for four days with or without the aid of detoxification medications.
• Lives within 50 miles of the study site.
• Speaks, understands and prints in English.

Exclusion Criteria:

• Ever abused or dependent on opiates or evidence of opiate use in month prior to treatment.
• Meets criteria for dependence on any substance other than alcohol (except nicotine).
• Tests positive on the urine drug screen at the initial visit.
• Meets criteria for panic, obsessive-compulsive, post-traumatic stress, or eating disorders.
• Meets current or lifetime criteria for bipolar affective disorder, schizophrenia or any psychiatric disorder, or organic mental disorder.
• Has evidence of or a history of significant hematological, pulmonary, endocrine, cardiovascular, renal, or gastrointestinal disease.
• Hepatocellular disease.
• Abnormal elevation in bilirubin.
• Needs treatment with any psychoactive medication including antiseizure medications.
• Current use of disulfiram.
• Has taken a monoamine oxidase inhibitors, serotonin reuptake inhibitor or opiate antagonist in the month prior to randomization.
• Is or has been taking an investigational drug within one month prior to study.
• Females who are pregnant, contemplating pregnancy in the next six months, nursing or not using an effective contraceptive birth control method (if relevant).