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| Sponsored by: |
House Ear Institute |
| Information provided by: | Office of Rare Diseases (ORD) |
| ClinicalTrials.gov Identifier: | NCT00004483 |
Purpose
OBJECTIVES:
I. Define the growth rates and clinical course of NF2-related tumors in patients with neurofibromatosis type 2. Associate growth rate with physical function.
| Condition |
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Schwannoma, Vestibular Neurofibromatosis 2 Meningioma |
| Genetics Home Reference related topics: | familial encephalopathy with neuroserpin inclusion bodies neurofibromatosis type 2 |
| MedlinePlus related topics: | Neurofibromatosis |
| Study Type: | Observational |
| Study Design: | Natural History, Longitudinal |
| Estimated Enrollment: | 100 |
| Study Start Date: | January 2002 |
PROTOCOL OUTLINE: Data on the clinical course and growth rate of NF2-related tumors in patients with neurofibromatosis 2. Patients are evaluated each year on a cranial and a spinal MRI, eye tests, hearing tests, quality of life, neurological tests, and physical functioning.
Eligibility
| Ages Eligible for Study: | 5 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
PROTOCOL ENTRY CRITERIA:
--Disease Characteristics--
Bilateral vestibular schwannoma OR Family history of neurofibromatosis 2 (first degree family relative) AND Unilateral vestibular schwannoma at under 30 years OR Any 2 of the following: Meningioma Glioma Schwannoma Juvenile posterior subcapsular lenticular opacity/juvenile cortical cataract
--Prior/Concurrent Therapy--
--Patient Characteristics--
Contacts and Locations| United States, California | |||||
| House Ear Institute | |||||
| Los Angeles, California, United States, 90057-9927 | |||||
| House Ear Institute |
| Study Chair: | William H. Slattery, III | House Ear Institute |
More Information
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Masuda, Ann. Slattery, William H. III, Fisher, Laurel M., Oppenheimer, Mark. Audiological Characteristics of Initial Presentation of NF2 Patients: Preliminary Results. Abstract submitted to: Combined Otolaryngological Spring Meetings (COSM).
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Fisher, Laurel M., Slattery, WIlliam H. III, Yoon, Gloria. MRI Test-Retest Study of NF2 Patients. Abstract Submitted to: Combined Otolaryngological Spring Meetings (COSM).
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Masuda A, Fisher LM, Oppenheimer ML, Iqbal Z, Slattery WH; Natural History Consortium. Hearing changes after diagnosis in neurofibromatosis type 2. Otol Neurotol. 2004 Mar;25(2):150-4.
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Slattery WH, Lev MH, Fisher LM, Connell SS, Iqbal Z, Go JL; NF2 Natural History Consortium. MRI evaluation of neurofibromatosis 2 patients: a standardized approach for accuracy in interpretation. Otol Neurotol. 2005 Jul;26(4):733-40.
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Slattery WH 3rd, Fisher LM, Iqbal Z, Oppenhiemer M. Vestibular schwannoma growth rates in neurofibromatosis type 2 natural history consortium subjects. Otol Neurotol. 2004 Sep;25(5):811-7.
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Zacharia, T., Lev, M., Iqbal, Z.T., Fisher ,L.M. , Gupta, MS, Slattery, WH.
(2003) Intramedullary Spinal Tumors In NF II: Incidence And Imaging
Characteristics American Radiology Society, 2003.
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| Study ID Numbers: | 199/14226, HEI-NF2, HEI-DAMD17-01-1-0710 |
| First Received: | October 18, 1999 |
| Last Updated: | September 27, 2005 |
| ClinicalTrials.gov Identifier: | NCT00004483 |
| Health Authority: | Unspecified |
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