Longitudinal and Biological Study of Childhood Disintegrative Disorder

This study has been terminated.

First Received: October 18, 1999 Last Updated: June 23, 2005 History of Changes

Sponsor:	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborator:	Yale University
Information provided by:	Office of Rare Diseases (ORD)
ClinicalTrials.gov Identifier:	NCT00004458

Purpose

OBJECTIVES:

I. Compare the developmental course (language acquisition, diagnostic stability, predictors of outcome, and restricted interests and behaviors) of childhood disintegrative disorder versus autism and non-autistic developmental delays.

II. Collect data on molecular genetics of proband and family members.

Condition
Pervasive Child Development Disorders Autism

Study Type:	Observational
Study Design:	Screening, Longitudinal

Resource links provided by NLM:

MedlinePlus related topics: Autism Child Development Developmental Disabilities Infant and Toddler Development

U.S. FDA Resources

Further study details as provided by Office of Rare Diseases (ORD):

Estimated Enrollment:	220
Study Start Date:	May 1997

Detailed Description:

PROTOCOL OUTLINE:

Patients are evaluated with the following questionnaires at ages 2-3 years and again at ages 5-9: The Autism Diagnostic Interview (ADI); The Autism Diagnostic Observation Schedule (ADOS); Assessment of cognitive functioning; Expressive and receptive language; Adaptive functioning; Measures of burden and functional assessment; The Aberrant Behavior Checklist; The Connors Rating Scale - Parent and Teacher version; and Autism Behavior Checklist

An MRI and EEG are performed, and blood samples are collected from patients and family members for molecular genetic studies.

Eligibility

Ages Eligible for Study:	2 Years to 9 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Psychologically diagnosed (DSM-IV) as Childhood Disintegrative Disorder
No known genetic or medical syndrome (Down syndrome or cerebral palsy)
Must speak English

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00004458

Locations

United States, Connecticut
Yale Child Study Center
New Haven, Connecticut, United States, 06520
United States, Illinois
University of Chicago Cancer Research Center
Chicago, Illinois, United States, 60637

Sponsors and Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Yale University

Investigators

Study Chair:

Fred Volkmar

Yale University

More Information

Publications:

Volkmar FR, Klin A, Marans WD, et al.: Childhood disintegrative disorder. In: Cohen DJ, Volkmar FR.: Handbook of autism and pervasive developmental disorders. 2nd ed., New York, NY: John Wiley, 1997, pp 47-59.

Study ID Numbers:	199/13682, YALE-5P01HD0300830, YALE-HIC-5895
Study First Received:	October 18, 1999
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00004458 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by Office of Rare Diseases (ORD):

autism
childhood disintegrative disorder
neurologic and psychiatric disorders
rare disease

Additional relevant MeSH terms:

Child Development Disorders, Pervasive
Developmental Disabilities
Pathologic Processes
Disease

Mental Disorders
Autistic Disorder
Mental Disorders Diagnosed in Childhood

ClinicalTrials.gov processed this record on November 05, 2009