Randomized Study of the Effects of Glucose on Cognition in Healthy Young and Elderly People and Parkinson's Disease Patients

This study has been completed.

First Received: October 18, 1999 Last Updated: November 29, 2005 History of Changes

Sponsor:	National Institute of Mental Health (NIMH)
Collaborator:	University of Virginia
Information provided by:	National Institute of Mental Health (NIMH)
ClinicalTrials.gov Identifier:	NCT00004451

Purpose

This study will determine whether glucose facilitates memory in healthy elderly people and those with Parkinson's disease.

Condition	Intervention
Parkinson Disease	Drug: Glucose

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind

Resource links provided by NLM:

Genetics Home Reference related topics: familial paroxysmal nonkinesigenic dyskinesia Parkinson disease

MedlinePlus related topics: Parkinson's Disease

Drug Information available for: Dextrose

U.S. FDA Resources

Further study details as provided by National Institute of Mental Health (NIMH):

Estimated Enrollment:	120
Study Start Date:	March 1998

Detailed Description:

Subjects fast for 8 hours before receiving a test to determine their blood glucose levels. Following this test, subjects are randomized to receive either a glucose or saccharin sweetened drink. A series of memory tests and an additional 3 blood glucose level tests are administered approximately 15 minutes later. A minimum of 1 week afterward, the subjects return and receive the alternate sweetener followed by additional memory tests.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Three groups of subjects are eligible for this study: Healthy young adults between ages 18 and 30; Healthy elderly adults between ages 60 and 90; AND Anyone diagnosed with Parkinson's disease

Exclusion Criteria:

Prior surgery to remove part of the stomach
Diabetes, Addison's, or Cushing's diseases

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00004451

Locations

United States, Virginia
University of Virginia
Charlottesville, Virginia, United States, 22908

Sponsors and Collaborators

National Institute of Mental Health (NIMH)

University of Virginia

Investigators

Study Chair:

Carol A. Manning

University of Virginia

More Information

No publications provided

Study ID Numbers:	199/13548, K07 MH01197
Study First Received:	October 18, 1999
Last Updated:	November 29, 2005
ClinicalTrials.gov Identifier:	NCT00004451 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Mental Health (NIMH):

Parkinson disease
neurologic and psychiatric disorders
rare disease

Additional relevant MeSH terms:

Movement Disorders
Parkinson Disease
Nervous System Diseases
Basal Ganglia Diseases

Central Nervous System Diseases
Parkinsonian Disorders
Neurodegenerative Diseases
Brain Diseases

ClinicalTrials.gov processed this record on November 05, 2009