Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia - Full Text View

Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia

This study has been completed.

Sponsors and Collaborators:	National Center for Research Resources (NCRR) University of California, San Diego
Information provided by:	National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:	NCT00004353

Purpose

OBJECTIVES: I. Study the metabolism of pyruvate and related problems in patients with lactic acidemia.

II. Define the nature of the metabolic defect.

Condition

Mitochondrial Myopathy
MELAS Syndrome
Lactic Acidosis

Genetics Home Reference related topics:

mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes mitochondrial neurogastrointestinal encephalopathy disease

MedlinePlus related topics:

Muscle Disorders

U.S. FDA Resources

Study Type:	Observational

Further study details as provided by National Center for Research Resources (NCRR):

Estimated Enrollment:	35
Study Start Date:	December 1978

Detailed Description:

PROTOCOL OUTLINE: Patients fast for 6 hours. Glucagon IM is administered after the 6 hour fast. Glucose level is measured at 0, 15, 30, 45, 60, and 90 minutes.

In children of sufficient size, alanine and lactic acid should also be measured at each or most of these time points.

Fasting continues for at least 18 hours. Glucagon IM is administered again at end of fast. Glucose level is measured at time 0, 15, 30, 45, 60, and 90 minutes.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

PROTOCOL ENTRY CRITERIA:

Diagnostically documented elevation in lactate, pyruvate, and/or alanine levels in lactic acidemia patients

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00004353

Locations


United States, California
	University of California San Diego Medical Center
	San Diego, California, United States, 92103-8757

Sponsors and Collaborators

National Center for Research Resources (NCRR)

University of California, San Diego

Investigators


Study Chair:	Richard H. Haas	University of California, San Diego

More Information

Study ID Numbers:	NCRR-M01RR00827-0071, UCSD-071
First Received:	October 18, 1999
Last Updated:	July 9, 2008
ClinicalTrials.gov Identifier:	NCT00004353
Health Authority:	United States: Federal Government

Keywords provided by National Center for Research Resources (NCRR):

MELAS syndrome

inborn errors of metabolism

lactic acidosis

mitochondrial myopathy

rare disease

Study placed in the following topic categories:

MELAS syndrome

Acidosis, Lactic

Metabolic Diseases

Rare Diseases

Central Nervous System Diseases

Mitochondrial Diseases

Brain Diseases

Acidosis

MELAS Syndrome

Metabolism, Inborn Errors

Muscular Diseases

Genetic Diseases, Inborn

Musculoskeletal Diseases

Neuromuscular Diseases

Mitochondrial Myopathies

Brain Diseases, Metabolic, Inborn

Metabolic disorder

Brain Diseases, Metabolic

Additional relevant MeSH terms:

Mitochondrial Encephalomyopathies

Pathologic Processes

Disease

Syndrome

Nervous System Diseases

Acid-Base Imbalance

ClinicalTrials.gov processed this record on November 30, 2008