OBJECTIVES:

• Determine whether intraperitoneal (IP) injections of epithelial ovarian carcinoma cells infected with ALVAC-hB7.1 and IP interferon gamma have acceptable toxicity and produce any clinical responses in patients with refractory ovarian epithelial cancer.

OUTLINE: This is a dose-escalation study of ALVAC-hB7.1 infected tumor cells.

Patients receive ALVAC-hB7.1 infected tumor cells intraperitoneally (IP) on days 4, 11, and 18. Patients also receive interferon gamma IP on days 8, 10, 15, and 17. In the absence of disease progression, up to 6 courses of therapy may be given. If insufficient tumor cells are available to continue treatment with tumor cell derived vaccine, interferon gamma may be given alone.

Cohorts of 3 to 6 patients receive escalating doses of ALVAC-hB7.1 infected tumor cells until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose at which no more than 2 of 6 patients experience dose-limiting toxicity.

Patients are followed every 6 months until disease progression.

PROJECTED ACCRUAL: A total of 12 patients will be accrued for this study.

DISEASE CHARACTERISTICS:

• Diagnosis of ovarian epithelial carcinoma
• Previously treated with an adequate course of platinum based chemotherapy
• Evidence of intraabdominal disease
• No significant adhesions

PATIENT CHARACTERISTICS:

Age:

• Any age

Performance status:

• Zubrod 0-2

Life expectancy:

• Not specified

Hematopoietic:

• Lymphocyte count at least 500/mm^3

Hepatic:

• Bilirubin no greater than 1.5 mg/dL
• SGOT less than 2.5 times upper limit of normal

Renal:

• Creatinine no greater than 1.5 mg/dL

Cardiovascular:

• No major disorder of the cardiovascular system

Pulmonary:

• No major disorder of the pulmonary system

Other:

• Not pregnant or nursing
• Fertile patients must use effective contraception
• Successful placement of peritoneal catheter
• No overt autoimmune disease

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• See Disease Characteristics

Endocrine therapy:

• No concurrent chronic steroid therapy

Radiotherapy:

• No prior radiotherapy

Surgery:

• Prior surgery allowed

Other:

• Recovered from prior therapy