Inclusion Criteria
Patients must have:
- HIV infection.
- Asymptomatic or mildly symptomatic.
- CD4 count 100 - 300 cells/mm3.
Prior Medication:
Allowed:
- Prior antiretroviral agents for up to 6 months per agent.
Exclusion Criteria
Co-existing Condition:
Patients with the following condition are excluded:
Unable or unwilling to comply with study procedures.
Concurrent Medication:
Excluded:
- Chemoprophylactic therapy for mycobacterial infection.
- Any nonstudy prescription medications without approval of investigator.
Patients with the following prior conditions are excluded:
- History of grade 3 or 4 toxicity to <= 600 mg/day AZT.
- History of intolerance to lactose.
- Chronic diarrhea within 6 months prior to study entry.
- Unexplained intermittent or chronic fever, defined as temperature >= 38.5 C for any 7 days within the 30 days prior to study entry.
Prior Medication:
Excluded:
- Antiretroviral therapy within 2 weeks prior to study entry.
- Prior HIV vaccines.
- Biological response modifiers within 30 days prior to study entry.
- Prior foscarnet.
- Any investigational drug with a washout < 5 half-lives prior to study entry.
- Any medications known to alter renal, hepatic, or hematologic / immunologic function (such as barbiturates, phenothiazines, cimetidine, immunomodulators, etc.) within 14 days prior to study entry.
Recent history of alcohol and/or drug abuse.