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| Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
| Information provided by: | National Institutes of Health Clinical Center (CC) |
| ClinicalTrials.gov Identifier: | NCT00001624 |
Purpose
Previous studies have shown that insulin may stimulate the release of endothelin (ET) from endothelial cells. This mechanism may contribute to the adverse vascular effects determined by chronic hyperinsulinemia. The aim of this study will be to evaluate the effect of local hyperinsulinemia on ET activity in the forearm circulation. To this purpose, we will assess the forearm blood flow response to ET receptor antagonism in control conditions and during intraarterial infusion of insulin. We will also measure changes in plasma ET-1 levels in response to the different pharmacological stimuli.
| Condition | Intervention | Phase |
|
Hyperinsulinemia |
Drug: Insulin |
Phase I |
| Drug Information available for: | Insulin BQ 123 |
| Study Type: | Interventional |
| Study Design: | Treatment, Safety Study |
| Official Title: | Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation |
| Estimated Enrollment: | 16 |
| Study Start Date: | March 1997 |
| Estimated Study Completion Date: | March 2000 |
Previous studies have shown that insulin may stimulate the release of endothelin (ET) from endothelial cells. This mechanism may contribute to the adverse vascular effects determined by chronic hyperinsulinemia. The aim of this study will be to evaluate the effect of local hyperinsulinemia on ET activity in the forearm circulation. To this purpose, we will assess the forearm blood flow response to ET receptor antagonism in control conditions and during intraarterial infusion of insulin. We will also measure changes in plasma ET-1 levels in response to the different pharmacological stimuli.
Eligibility
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Between 40-65 years old.
No medications.
No medical problems.
No serum cholesterol levels below 200 mg/dl.
No contraceptives.
Contacts and Locations
More Information
| Study ID Numbers: | 970100, 97-H-0100 |
| First Received: | November 3, 1999 |
| Last Updated: | March 3, 2008 |
| ClinicalTrials.gov Identifier: | NCT00001624 |
| Health Authority: | United States: Federal Government |
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