Technical evaluation of magnetic resonance imaging and spectroscopy will be performed on normal volunteers. These studies may involve the intravenous administration of commercially available MR contrast media. The results will be used to evaluate the performance of various pulse sequences, gradient coils, and rf coils on human subjects and will provide essential ground work for specific patient protocols.

• INCLUSION CRITERIA:

Any normal volunteer above the age of 18 who is capable of giving informed consent.

EXCLUSION CRITERIA:

A subject will be excluded if he/she has a contraindication to MR scanning such as:

Brain aneurysm clip;

Implanted neural stimulator;

Implanted cardiac pacemaker or defibrillator;

Cochlear implant;

Ocular foreign body (e.g. metal shavings);

Insulin pump.

Subjects will be excluded if it is deemed that they have a condition which would preclude their use for technical development (e.g. paralyzed hemidiaphragm, morbid obesity, claustrophobia, etc.) or present unnecessary risk (e.g. pregnancy, surgery of uncertain type, etc.).

Lactating women and subjects with hemoglobinopathies, asthma, or renal or hepatic disease will be excluded from studies involving the administration of contrast agents.