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Studying Patients With a Personal or Family History of Cancer Caused by a Virus

This study is currently recruiting participants.
Verified by National Cancer Institute (NCI), March 2008

Sponsored by: National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT00556582
  Purpose

RATIONALE: Gathering information about patients with a personal or family history of cancer associated with a virus may help doctors learn more about the disease.

PURPOSE: This clinical trial is studying patients with a personal or family history of cancer caused by a virus.


Condition Intervention
Lymphoma
Sarcoma
Small Intestine Cancer
Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Childhood Solid Tumor, Protocol Specific
Procedure: biologic sample preservation procedure
Procedure: biopsy
Procedure: cytology specimen collection procedure
Procedure: immunologic technique
Procedure: study of high risk factors

MedlinePlus related topics:   Cancer    Intestinal Cancer    Lymphoma    Soft Tissue Sarcoma   

ChemIDplus related topics:   Salicylsalicylic acid    Sodium salicylate   

U.S. FDA Resources

Study Type:   Observational
Official Title:   Clinical, Laboratory and Epidemiologic Pilot Studies of Individuals at High Risk for Viral-Associated Cancers

Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Clinical, laboratory, and epidemiologic studies of patients with a personal or family history of viral-associated cancer

Estimated Enrollment:   200
Study Start Date:   December 1996
Estimated Primary Completion Date:   December 2010 (Final data collection date for primary outcome measure)

Detailed Description:

OBJECTIVES:

  • Conduct clinical, laboratory, and epidemiologic studies of patients with a personal or family history of viral-associated cancer.

OUTLINE: Patients undergo an interview, physical examination, and blood sample collection. Other clinically indicated biological samples, such as urine, sputum, saliva, tears, or semen or cervical, anal, oral, or nasal swabs, are collected. Skin testing with conventional, licensed antigens for assessment of cellular immunity may be performed, and skin lesions may be biopsied or excised. Tumor or other tissue biopsies may be obtained when biopsy or surgery is clinically indicated. The biological samples are frozen or preserved for current or future research studies.

Patients receive counseling relevant to the disease under study, and about the interim study results. Clinical referrals are made as needed.

  Eligibility
Ages Eligible for Study:   up to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Criteria

DISEASE CHARACTERISTICS:

  • Personal or family history of viral-associated neoplasia of an unusual type, pattern, or number including, but not limited to, the following:

    • Kaposi sarcoma
    • Leukemia
    • Lymphoma
  • Known or suspected factor(s) predisposing to neoplasia, including any of the following:

    • Environmental exposure (particularly immunological or virological exposure)
    • Genetic or congenital factors (e.g., Mendelian traits predisposing to neoplasia, birth defects, or chromosomal anomalies)
    • Unusual demographic features
  • Referred to the National Cancer Institute (NCI) Viral Epidemiology Branch

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00556582

Locations
United States, Maryland
Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office     Recruiting
      Bethesda, Maryland, United States, 20892-1182
      Contact: Clinical Trials Office - Warren Grant Magnusen Clinical Center     888-NCI-1937        

Sponsors and Collaborators

Investigators
Principal Investigator:     James J. Goedert, MD     National Cancer Institute (NCI)    
  More Information

Clinical trial summary from the National Cancer Institute's PDQ® database  This link exits the ClinicalTrials.gov site
 

Study ID Numbers:   CDR0000566031, NCI-97-C-0028
First Received:   November 9, 2007
Last Updated:   July 23, 2008
ClinicalTrials.gov Identifier:   NCT00556582
Health Authority:   Unspecified

Keywords provided by National Cancer Institute (NCI):
Kaposi sarcoma  
AIDS-related lymphoma  
adult Hodgkin lymphoma  
childhood Hodgkin lymphoma  
angioimmunoblastic T-cell lymphoma  
adult Burkitt lymphoma  
adult diffuse large cell lymphoma  
adult diffuse mixed cell lymphoma  
adult diffuse small cleaved cell lymphoma  
adult immunoblastic large cell lymphoma  
small intestine lymphoma  
intraocular lymphoma  
primary central nervous system lymphoma  
post-transplant lymphoproliferative disorder
adult grade III lymphomatoid granulomatosis
childhood grade III lymphomatoid granulomatosis
childhood immunoblastic large cell lymphoma
childhood diffuse large cell lymphoma
childhood small noncleaved cell lymphoma
Burkitt lymphoma
adult T-cell leukemia/lymphoma
unspecified adult solid tumor, protocol specific
unspecified childhood solid tumor, protocol specific
adult nasal type extranodal NK/T-cell lymphoma
childhood nasal type extranodal NK/T-cell lymphoma

Study placed in the following topic categories:
Hodgkin's disease
Primary effusion lymphoma
Gastrointestinal Diseases
Hodgkin lymphoma, adult
Malignant mesenchymal tumor
Sodium Salicylate
Lymphoma, small cleaved-cell, diffuse
Small non-cleaved cell lymphoma
Lymphoma, large-cell, immunoblastic
Soft tissue sarcomas
Central nervous system lymphoma, primary
Lymphoma, large-cell
Duodenal Neoplasms
Lymphomatoid granulomatosis
Burkitt's lymphoma
Neoplasms, Connective and Soft Tissue
Leukemia
Kaposi sarcoma
Lymphoma, AIDS-Related
Ileal Neoplasms
Lymphoma, T-Cell
Lymphoma, Large-Cell, Immunoblastic
Hodgkin Disease
Lymphoma
Duodenal Diseases
Lymphoma, AIDS-related
Jejunal Neoplasms
Lymphoma, Large B-Cell, Diffuse
Lymphomatoid Granulomatosis
Immunoproliferative Disorders

Additional relevant MeSH terms:
Neoplasms
Neoplasms by Site
Neoplasms by Histologic Type
Immune System Diseases
Jejunal Diseases
Ileal Diseases

ClinicalTrials.gov processed this record on September 05, 2008




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