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Studying Patients With a Personal or Family History of Cancer Caused by a Virus
This study is currently recruiting participants.
Verified by National Cancer Institute (NCI), December 2008
First Received: November 9, 2007   Last Updated: February 6, 2009   History of Changes
Sponsored by: National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT00556582
  Purpose

RATIONALE: Gathering information about patients with a personal or family history of cancer associated with a virus may help doctors learn more about the disease.

PURPOSE: This clinical trial is studying patients with a personal or family history of cancer caused by a virus.


Condition Intervention
Lymphoma
Lymphoproliferative Disorder
Sarcoma
Small Intestine Cancer
Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Childhood Solid Tumor, Protocol Specific
Other: biologic sample preservation procedure
Other: cytology specimen collection procedure
Other: immunologic technique
Procedure: biopsy
Procedure: study of high risk factors

Study Type: Observational
Official Title: Clinical, Laboratory and Epidemiologic Pilot Studies of Individuals at High Risk for Viral-Associated Cancers

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Clinical, laboratory, and epidemiologic studies of patients with a personal or family history of viral-associated cancer

Estimated Enrollment: 200
Study Start Date: December 1996
Estimated Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Detailed Description:

OBJECTIVES:

  • Conduct clinical, laboratory, and epidemiologic studies of patients with a personal or family history of viral-associated cancer.

OUTLINE: Patients undergo an interview, physical examination, and blood sample collection. Other clinically indicated biological samples, such as urine, sputum, saliva, tears, or semen or cervical, anal, oral, or nasal swabs, are collected. Skin testing with conventional, licensed antigens for assessment of cellular immunity may be performed, and skin lesions may be biopsied or excised. Tumor or other tissue biopsies may be obtained when biopsy or surgery is clinically indicated. The biological samples are frozen or preserved for current or future research studies.

Patients receive counseling relevant to the disease under study, and about the interim study results. Clinical referrals are made as needed.

  Eligibility

Ages Eligible for Study:   up to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Personal or family history of viral-associated neoplasia of an unusual type, pattern, or number including, but not limited to, the following:

    • Kaposi sarcoma
    • Leukemia
    • Lymphoma
  • Known or suspected factor(s) predisposing to neoplasia, including any of the following:

    • Environmental exposure (particularly immunological or virological exposure)
    • Genetic or congenital factors (e.g., Mendelian traits predisposing to neoplasia, birth defects, or chromosomal anomalies)
    • Unusual demographic features
  • Referred to the National Cancer Institute (NCI) Viral Epidemiology Branch

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00556582

Locations
United States, Maryland
Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office Recruiting
Bethesda, Maryland, United States, 20892-1182
Contact: Clinical Trials Office - Warren Grant Magnusen Clinical Center     888-NCI-1937        
Sponsors and Collaborators
Investigators
Principal Investigator: James J. Goedert, MD National Cancer Institute (NCI)
  More Information

Additional Information:
No publications provided

Study ID Numbers: CDR0000566031, NCI-97-C-0028
Study First Received: November 9, 2007
Last Updated: February 6, 2009
ClinicalTrials.gov Identifier: NCT00556582     History of Changes
Health Authority: Unspecified

Keywords provided by National Cancer Institute (NCI):
Kaposi sarcoma
AIDS-related lymphoma
adult Hodgkin lymphoma
childhood Hodgkin lymphoma
angioimmunoblastic T-cell lymphoma
adult Burkitt lymphoma
adult diffuse large cell lymphoma
adult diffuse mixed cell lymphoma
adult diffuse small cleaved cell lymphoma
adult immunoblastic large cell lymphoma
small intestine lymphoma
intraocular lymphoma
primary central nervous system lymphoma
post-transplant lymphoproliferative disorder
adult grade III lymphomatoid granulomatosis
childhood grade III lymphomatoid granulomatosis
childhood immunoblastic large cell lymphoma
childhood diffuse large cell lymphoma
childhood small noncleaved cell lymphoma
Burkitt lymphoma
adult T-cell leukemia/lymphoma
unspecified adult solid tumor, protocol specific
unspecified childhood solid tumor, protocol specific
adult nasal type extranodal NK/T-cell lymphoma
childhood nasal type extranodal NK/T-cell lymphoma

Study placed in the following topic categories:
Hodgkin Lymphoma, Childhood
Gastrointestinal Diseases
Central Nervous System Lymphoma, Primary
Ileal Diseases
Lymphoma, Large-cell, Immunoblastic
Kaposi Sarcoma
Lymphoma, Small Cleaved-cell, Diffuse
Duodenal Neoplasms
Neoplasms, Connective and Soft Tissue
Leukemia
Soft Tissue Sarcomas
Lymphoma, AIDS-Related
Ileal Neoplasms
Lymphoma, T-Cell
Lymphoma, Large-Cell, Immunoblastic
Lymphoma, Large-cell
Hodgkin Disease
Lymphoma
Duodenal Diseases
Lymphoma, AIDS-related
Jejunal Neoplasms
Lymphoma, Large B-Cell, Diffuse
Lymphomatoid Granulomatosis
Immunoproliferative Disorders
Digestive System Neoplasms
Hodgkin Lymphoma, Adult
Leukemia-Lymphoma, Adult T-Cell
Sarcoma, Kaposi
Immunoblastic Lymphadenopathy
Hodgkin's Disease

Additional relevant MeSH terms:
Jejunal Neoplasms
Digestive System Neoplasms
Neoplasms by Histologic Type
Immunoproliferative Disorders
Immune System Diseases
Gastrointestinal Diseases
Intestinal Diseases
Ileal Diseases
Intestinal Neoplasms
Duodenal Neoplasms
Neoplasms, Connective and Soft Tissue
Lymphatic Diseases
Neoplasms
Digestive System Diseases
Neoplasms by Site
Ileal Neoplasms
Jejunal Diseases
Sarcoma
Gastrointestinal Neoplasms
Lymphoproliferative Disorders
Lymphoma
Duodenal Diseases

ClinicalTrials.gov processed this record on July 02, 2009