Genetic Aspects of Neurologic and Psychiatric Disorders - Full Text View

Purpose

The purpose of this study is to improve the understanding of the genetic causes of specific neurologic and psychiatric disorders. The study will focus on conditions of mental retardation, childhood onset schizophrenia, attention deficit hyperactivity disorder (ADHD), atypical psychosis of childhood, and bipolar affective disorder.

The study addresses the belief that there may be several genes contributing to the illness. Researchers intend to use several molecular genetic techniques in order to identify the areas of chromosomes containing genes responsible for the development of these disorders.

Patients will be selected to participate in this study based on an early age of onset of their condition as well as the severity of the illness and the frequency of the illness among family members. Researchers will collect DNA samples from patients as well as affected and unaffected family members of each patient. The DNA samples collected will be analyzed for a variety of genetic abnormalities including; triplet repeat expansions, chromosome rearrangements, and polymorphisms.

Condition

Attention Deficit Disorder With Hyperactivity
Bipolar Disorder
Mental Disorder Diagnosed in Childhood
Mental Retardation
Schizophrenia

MedlinePlus related topics:

Attention Deficit Hyperactivity Disorder Bipolar Disorder Child Mental Health Mental Health Schizophrenia

U.S. FDA Resources

Study Type:	Observational

Official Title:	Genetic Aspects of Neurologic and Psychiatric Disorders

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	1227
Study Start Date:	April 1996
Estimated Study Completion Date:	March 2004

Detailed Description:

We propose to use DNA probes to study patients having specific neurologic and psychiatric disorders, especially focusing on patients with early onset or extreme phenotypes such as childhood onset schizophrenia (COS), mental retardation (MR), attention deficit hyperactivity disorder (ADHD), atypical psychosis of childhood, (multi-dimensional impairment MDI), and bipolar affective disorder (BPAD). This study addresses the hypothesis that genetic risk factors contribute to these diverse phenotypes. Several complementary molecular genetic techniques are employed to identify chromosomal regions containing genes contributing to specific neurologic and psychiatric disorders. Patients will be selected for this study on the basis of the age of onset and severity of neurologic or psychiatric symptoms, familial genetic loading and family structure. Individuals participating in this protocol will be clinically evaluated through other NIMH or NIH clinical protocols, particularly through those of the Child Psychiatry Branch (reference protocol numbers 85-M-0115, 84-M-0050, 97-M-0126). Those subjects meeting inclusion criteria may undergo a screening that may include physical, neurologic or psychiatric examinations. As appropriate, this initial screen may be followed by more formal, structured instruments such as the Schedule for Affective Disorders (SADS), the revised Weschler Adult Intelligence Scale (WAIS-R), the Conner's revised parent and teacher ratings, and the Diagnostic Interview for Children and Adolescents (DICA- version IV) to confirm the clinical diagnosis at the discretion of the treating physician. Venipuncture and/or buccal swabs will be performed in order to obtain samples for DNA extraction or to establish a lymphoblast cell line to be used in genetic tests. Samples will also be collected from family members and controls for these studies.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

INCLUSION CRITERIA:

Individuals with selected psychiatric and neurologic disorders, including childhood onset schizophrenia, atypical psychosis, mental retardation, bipolar affective disorder, and ADHD.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00001544

Locations


United States, Maryland
	National Institute of Mental Health (NIMH)
	Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Institute of Mental Health (NIMH)

More Information

Publications:

Willems PJ. Dynamic mutations hit double figures. Nat Genet. 1994 Nov;8(3):213-5. No abstract available.

Koide R, Ikeuchi T, Onodera O, Tanaka H, Igarashi S, Endo K, Takahashi H, Kondo R, Ishikawa A, Hayashi T, et al. Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Nat Genet. 1994 Jan;6(1):9-13.

Philibert RA, Hawkins GA, Damschroder-Williams P, Stubblefield BK, Martin BM, Ginns EI. Direct sequencing of trinucleotide repeats from cosmid genomic DNA template. Anal Biochem. 1995 Mar 1;225(2):372-4. No abstract available.

Study ID Numbers:	960060, 96-M-0060
First Received:	November 3, 1999
Last Updated:	March 3, 2008
ClinicalTrials.gov Identifier:	NCT00001544
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

DNA Probes

Trinucleotide Repeats

Family Studies

Lymphoblast Cell Lines

Genotyping

Bipolar Affective Disorders

Schizophrenia

Mental Retardation

Neuropsychiatric Disorders

Study placed in the following topic categories:

Bipolar Disorder

Attention Deficit and Disruptive Behavior Disorders

Dyskinesias

Mental Retardation

Schizophrenia

Signs and Symptoms

Affective Disorders, Psychotic

Attention Deficit Disorder with Hyperactivity

Mental Disorders

Mental Disorders Diagnosed in Childhood

Mood Disorders

Hyperkinesis

Neurologic Manifestations

Psychotic Disorders

Neurobehavioral Manifestations

Schizophrenia and Disorders with Psychotic Features

Additional relevant MeSH terms:

Pathologic Processes

Disease

Nervous System Diseases

ClinicalTrials.gov processed this record on November 30, 2008

Sponsored by:	National Institute of Mental Health (NIMH)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00001544