OBJECTIVES:

• Determine the maximum tolerated dose of paclitaxel when combined with carboxyamidotriazole in patients with advanced solid tumors or refractory lymphomas.
• Determine the pharmacokinetics and toxicities of this regimen in these patients.
• Identify diseases for which this combination appears active.

OUTLINE: This is a dose escalation study.

Patients receive oral carboxyamidotriazole (CAI) daily with paclitaxel IV over 3 hours on day 8 and every 3 weeks thereafter. Course 1 is 28 days and all other subsequent courses are 21 days. Treatment continues in the absence of disease progression or unacceptable toxicity. Patients who achieve complete response receive 2 additional courses of treatment.

Sequential dose escalation of CAI is followed by sequential dose escalation of paclitaxel. Dose escalation in cohorts of 3 to 6 patients each continues until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose limiting toxicity.

PROJECTED ACCRUAL: A total of 70 patients will be accrued for this study.

DISEASE CHARACTERISTICS:

• Histologically diagnosed solid tumor (i.e., breast and ovarian epithelial carcinomas) or lymphoma

  • Slides reviewed at the NCI Laboratory of Pathology

• Failure on therapy of proven efficacy for the disease

  • Prior therapy not required for the following metastatic diseases:

    • Melanoma
    • Non-small cell lung cancer
    • Renal cell carcinoma

• No brain metastases

  • Primary brain tumors (such as glioblastoma multiforme) with stable neurologic deficits allowed

• Measurable or evaluable disease required

  • Demonstrated by physical exam or on radiograph within 2 weeks prior to initiation of treatment OR

  • Elevated PSA associated with prostate cancer

    • Other marker-only disease ineligible

PATIENT CHARACTERISTICS:

Age:

• Over 18

Performance status:

• ECOG 0-2

Life expectancy:

• At least 3 months

Hematopoietic:

• WBC at least 3,000/mm^3
• Platelet count at least 100,000/mm^3
• Hematocrit at least 27%

Hepatic:

• Liver function tests no greater than 2 times upper limit of normal
• Bilirubin normal
• PT or PTT no greater than 1.25 times upper limit of normal
• Clotting parameters normal
• No concurrent anticoagulants other than 1 mg of warfarin per day for prophylaxis

Renal:

• Creatinine no greater than 1.5 mg/dL OR
• Creatinine clearance at least 45 mL/min
• No kidney obstruction

Cardiovascular:

• No cardiac conduction defect requiring antiarrhythmics
• No evidence of myocardial infarction or other myocardial damage within past 6 months

Other:

• HIV negative
• No concurrent infection
• No guaiac-positive stool test
• No neuropathy greater than grade I (unless associated with fixed-deficit primary brain tumors)
• Not pregnant or nursing
• Fertile patients must use effective contraception during and for 2 months after study

PRIOR CONCURRENT THERAPY:

• Recovery from prior therapy required

Biologic therapy:

• At least 4 weeks since prior biologic therapy

Chemotherapy:

• At least 4 weeks since prior chemotherapy (6 weeks since mitomycin, nitrosoureas, or carboplatin)
• No progression on carboxyamidotriazole or paclitaxel
• At least 6 months between treatment and relapse

Endocrine therapy:

• At least 4 weeks since prior hormonal therapy
• No concurrent corticosteroids except as physiologic replacement

Radiotherapy:

• At least 4 weeks since prior radiotherapy

Surgery:

• Not specified

Other:

• At least 1 week since prior therapeutic antibiotics
• Concurrent prophylactic antibiotics allowed except imidazole antifungals (e.g., ketoconazole, fluconazole)
• No concurrent calcium channel blockers