Study of Psoriatic Arthritis - Full Text View

Purpose

This study will examine the genetic and immune factors involved in the cause and development of psoriatic arthritis-a disease of both the skin and joints. It will describe the medical features and natural course of the disease and determine participants' eligibility for experimental treatment protocols.

Patients with known or suspected psoriatic arthritis 5 years of age and older and their relatives may enroll in this study. Patients will be evaluated with a medical history and physical examination, electrocardiogram, blood tests and X-rays. Additional procedures may include:

Leukapheresis-Collection of white blood cells for genetic analysis. Whole blood is collected through a needle placed in an arm vein. The blood circulates through a machine that separates it into its components. The plasma is removed and the cells are returned to the body through a second needle placed in the other arm.
Skin biopsy-Removal of a small skin sample for microscopic analysis. An area of skin is numbed with an anesthetic and one to three small circular portions (about 1/4 inch in diameter) are cut and removed.
Joint aspiration-Removal of a small sample of synovial fluid (lubricating joint fluid). An area of skin around the biopsy site is numbed with an anesthetic, and a needle is inserted into the joint to pull out a small fluid sample.
Synovial needle biopsy-Removal of a small sample of synovial tissue (tissue lining the joint). An area of skin around the biopsy site is numbed with an anesthetic and a large needle is inserted into the joint. A smaller needle attached to a syringe is then placed inside the larger needle and small pieces of synovial tissue are removed.
Genetic studies-Saliva and blood samples will be collected for gene testing. Saliva is collected by rinsing the mouth with a tablespoon of salt water and spitting into a test tube.

Patients will be followed once or twice a year and may be evaluated for participation in an experimental treatment study.

Participating relatives of patients will fill out a brief medical history questionnaire and provide a DNA sample (blood sample or tissue swab from the inside of the cheek).

Condition

Psoriasis
Psoriatic Arthritis

MedlinePlus related topics:

Psoriasis Skin Conditions

U.S. FDA Resources

Study Type:	Observational

Official Title:	Studies of the Pathogenesis and Natural History of Psoriatic Arthritis

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	999
Study Start Date:	March 1995
Estimated Study Completion Date:	January 2006

Detailed Description:

Patients with known or suspected psoriatic arthritis will be evaluated at the Clinical Center. Studies will include characterization of the clinical and laboratory features of the disease, research studies of the natural history and pathogenesis, genetic studies, and determination of the patient's eligibility to enter experimental therapeutic protocols. Patients may be asked to contribute blood, skin or synovial membrane samples for immunologic and genetic research studies.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

INCLUSION CRITERIA:

Psoriatic arthritis (proven or suspected) or;

Family history of psoriasis or psoriatic arthritis (i.e. family members of patients with psoriasis or psoriatic arthritis); and

Willingness and ability of the subject or guardian to give informed consent.

EXCLUSION CRITERIA:

Concomitant medical problems which would confound the interpretation of immunological studies.

Concomitant medical, surgical or other conditions for which inadequate facilities or funds are available to support their care at the NIH.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00001420

Locations


United States, Maryland
	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
	Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

More Information

Publications:

Barker JN. The pathophysiology of psoriasis. Lancet. 1991 Jul 27;338(8761):227-30. Review. No abstract available.

Espinoza LR, Cuellar ML, Silveira LH. Psoriatic arthritis. Curr Opin Rheumatol. 1992 Aug;4(4):470-8. Review.

Moll JM, Wright V. Psoriatic arthritis. Semin Arthritis Rheum. 1973;3(1):55-78. Review. No abstract available.

Study ID Numbers:	950082, 95-AR-0082
First Received:	November 3, 1999
Last Updated:	March 3, 2008
ClinicalTrials.gov Identifier:	NCT00001420
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Lymphocytes

Cytokines

Apoptosis

Psoriasis

Genetics

Psoriatic Arthritis

Study placed in the following topic categories:

Spinal Diseases

Skin Diseases

Musculoskeletal Diseases

Psoriasis

Arthritis, Psoriatic

Spondylarthropathy

Joint Diseases

Arthritis

Skin Diseases, Papulosquamous

Bone Diseases

Spondylarthritis

Spondylarthropathies

ClinicalTrials.gov processed this record on September 05, 2008

Sponsored by:	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00001420