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Diabetic Retinopathy and Visual Function Study

This study has been completed.

Sponsored by: National Eye Institute (NEI)
Information provided by: National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier: NCT00001346
  Purpose

The purpose of this study is to evaluate possible mechanisms of central visual loss in patients with diabetes mellitus. The visual loss of interest to be investigated is that associated with macular edema (prior to and following laser photocoagulation treatment) and that associated with panretinal photocoagulation. The evaluation will be performed with psychophysical testing, i.e., static perimetry and contrast sensitivity function. Of particular interest, the mechanisms of visual loss associated with macular edema (prior to and following laser photocoagulation) will be further investigated. Photoreceptor-mediated visual loss will be assessed by measurements of the Stiles-Crawford effect. Visual loss mediated by post-receptoral retinal changes will be assessed by measuring the Westheimer spatial desensitization/sensitization effect.


Condition
Diabetic Retinopathy
Macular Degeneration
Vision, Subnormal

Genetics Home Reference related topics:   X-linked juvenile retinoschisis   

MedlinePlus related topics:   Diabetic Eye Problems    Edema    Macular Degeneration    Retinal Disorders   

U.S. FDA Resources

Study Type:   Observational
Official Title:   Diabetic Retinopathy and Visual Function Study

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:   100
Study Start Date:   November 1992
Estimated Study Completion Date:   October 2000

Detailed Description:

The purpose of this study is to evaluate possible mechanisms of central visual loss in patients with diabetes mellitus. The visual loss of interest to be investigated is that associated with macular edema (prior to and following laser photocoagulation treatment) and that associated with panretinal photocoagulation. The evaluation will be performed with psychophysical testing, i.e., static perimetry and contrast sensitivity function. Of particular interest, the mechanisms of visual loss associated with macular edema (prior to and following laser photocoagulation) will be further investigated. Photoreceptor-mediated visual loss will be assessed by measurements of the Stiles-Crawford effect. Visual loss mediated by post-receptoral retinal changes will be assessed by measuring the Westheimer spatial desensitization/sensitization effect.

  Eligibility
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Criteria

Patients with diabetic retinopathy that has not been previously treated are eligible for the study.

Patients who have had laser photocoagulation (either focal or scatter) are not eligible.

  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00001346

Locations
United States, Maryland
National Eye Institute (NEI)    
      Bethesda, Maryland, United States, 20892

Sponsors and Collaborators
  More Information

Publications:

Study ID Numbers:   930037, 93-EI-0037
First Received:   November 3, 1999
Last Updated:   March 3, 2008
ClinicalTrials.gov Identifier:   NCT00001346
Health Authority:   United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Diabetic Macular Edema  
Diabetic Retinopathy  
Macular Edema  
Photocoagulation
Psychophysical Testing
Stiles-Crawford Effect

Study placed in the following topic categories:
Sensation Disorders
Vision Disorders
Eye Diseases
Vascular Diseases
Diabetes Mellitus
Macular Degeneration
Edema
Endocrine System Diseases
Retinal Degeneration
Vision, Low
Diabetic Angiopathies
Signs and Symptoms
Macular Edema
Diabetic Retinopathy
Neurologic Manifestations
Endocrinopathy
Retinal Diseases
Diabetes Complications
Retinal degeneration

Additional relevant MeSH terms:
Nervous System Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on August 28, 2008




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