Inclusion Criteria

Concurrent Medication:

Allowed:

• Aerosolized pentamidine 300 mg per 4 weeks.
• Drugs unlikely to cause increased toxicity with either study drug and unlikely to cause peripheral neuropathy.
• Drugs with little nephrotoxicity, hepatotoxicity, or cytotoxicity, that patient has been taking and tolerating well for ongoing condition.
• Acyclovir (= or < 600 mg/day, orally).
• Ketoconazole (= or < 400 mg/day).
• Nystatin (occasional).
• Acetaminophen or nonsteroidal antiinflammatory agents (low dose).
• Drugs that could possibly cause serious additive toxicity when coadministered with either study drug, but unlikely to cause peripheral are allowed only if their use is anticipated for treatment of acute intercurrent illness or opportunistic infections.
• Allowed only with a study drug interruption of up to 21 days per episode, for a total of 42 days for the study:
• Acyclovir (> 600 mg/day).
• Experimental drugs including ganciclovir.
• Fluconazole.
• Systemic pentamidine.
• Pyrimethamine.
• Triple sulfa.
• Ansamycin.
• Prolonged continuous use of high-dose nonsteroidal antiinflammatory agents.
• Acetaminophen.
• Amphotericin.
• Foscarnet.

Concurrent Treatment:

Allowed:

• Radiation therapy if unlikely to cause peripheral neuropathy if their use is anticipated for treatment of acute intercurrent illness or opportunistic infection.
• Transfusion for anemia.

Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

• Active opportunistic infections requiring treatment with unallowed drugs.
• Symptomatic visceral Kaposi's sarcoma (KS), progression of KS within month prior to study entry, or with concurrent neoplasms other than KS, basal cell carcinoma of the skin, or in situ carcinoma of the cervix.
• History of peripheral neuropathy or any significant signs or symptoms of neurological disease, or abnormality indicative of peripheral neuropathy.
• Significant cardiac disease defined as history of ventricular arrhythmias requiring medication, prior myocardial infarction, or history of angina or ischemic changes on electrocardiogram.
• Significant liver disease as defined by transaminase levels or by history of cirrhosis or ascites.
• Significant renal disease defined by serum creatinine.

Concurrent Medication:

Excluded:

• Experimental drugs including fluconazole, and foscarnet.
• Immunomodulators including interferon, interleukins, or systemic corticosteroids.
• Ganciclovir.
• Neurotoxic drugs.
• Drugs that could potentially cause peripheral neuropathy, including chloramphenicol, cisplatin, iodoquinol, dapsone, phenytoin, disulfiram, ethionamide, glutethimide, gold, hydralazine, isoniazid, metronidazole, vincristine, and nitrofurantoin.
• Excluded within 4 weeks of study entry:
• Drugs that have caused significant nephrotoxicity or significant hepatotoxicity (as defined by transaminases).

Concurrent Treatment:

Excluded:

• Transfusion dependent.

Patients are excluded if unwilling or unable to sign informed consent.

Prior Medication:

Excluded:

• Zidovudine (AZT).
• Dideoxycytidine (ddC).
• Any other nucleoside antiretrovirals.

Positive antibody to HIV using any federally licensed ELISA test kit. Diagnosis of AIDS or AIDS-related complex (ARC).

Active substance or alcohol abuse.