Intracellular Pharmacokinetics of Zidovudine Triphosphate in Maternal and Infant Cord Blood Mononuclear Cells.
This study has been completed.
Information provided by:
National Institute of Allergy and Infectious Diseases (NIAID)
First received: November 2, 1999
Last updated: June 23, 2005
Last verified: March 1998
To determine the levels of zidovudine triphosphate ( AZT-TP ) in maternal and fetal cord blood mononuclear cells. To determine the ratio of AZT-TP to endogenous nucleoside triphosphate levels in maternal and fetal cells. To determine the extent of drug transfer through the feto/placental unit.
||Observational Model: Natural History
||Intracellular Pharmacokinetics of Zidovudine Triphosphate in Maternal and Infant Cord Blood Mononuclear Cells.
|Ages Eligible for Study:
||18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00000830
|Univ of Medicine & Dentistry of New Jersey / Univ Hosp
|Newark, New Jersey, United States, 071032714 |
|Bellevue Hosp / New York Univ Med Ctr
|New York, New York, United States, 10016 |
|Mount Sinai Med Ctr / Pediatrics
|New York, New York, United States, 10029 |
|Regional Med Ctr at Memphis
|Memphis, Tennessee, United States, 38103 |
|Saint Jude Children's Research Hosp of Memphis
|Memphis, Tennessee, United States, 381052794 |
|San Juan City Hosp
|San Juan, Puerto Rico, 009367344 |
Rodman JH, Flynn PM, Robbins BL, Blanchard S, Jimenez E, Rodriguez J, Fridland A. Zidovudine pharmacokinetics and intracellular pharmacology of zidovudine in HIV-infected women and newborn infants. Conf Retroviruses Opportunistic Infect. 1999 Jan 31-Feb 4;6th:146 (abstract no 419)
History of Changes
|Other Study ID Numbers:
|Study First Received:
||November 2, 1999
||June 23, 2005
||United States: Federal Government
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on November 23, 2014
Acquired Immunodeficiency Syndrome
Immune System Diseases
Immunologic Deficiency Syndromes
RNA Virus Infections
Sexually Transmitted Diseases
Sexually Transmitted Diseases, Viral
Slow Virus Diseases
Molecular Mechanisms of Pharmacological Action
Nucleic Acid Synthesis Inhibitors
Reverse Transcriptase Inhibitors