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| Sponsored by: |
National Institute of Allergy and Infectious Diseases (NIAID) |
| Information provided by: | National Institute of Allergy and Infectious Diseases (NIAID) |
| ClinicalTrials.gov Identifier: | NCT00000830 |
Purpose
To determine the levels of zidovudine triphosphate ( AZT-TP ) in maternal and fetal cord blood mononuclear cells. To determine the ratio of AZT-TP to endogenous nucleoside triphosphate levels in maternal and fetal cells. To determine the extent of drug transfer through the feto/placental unit.
| Condition |
|
HIV Infections Pregnancy |
| MedlinePlus related topics: | AIDS |
| Drug Information available for: | Zidovudine |
| Study Type: | Observational |
| Study Design: | Natural History |
| Official Title: | Intracellular Pharmacokinetics of Zidovudine Triphosphate in Maternal and Infant Cord Blood Mononuclear Cells. |
Eligibility
| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
Contacts and Locations| United States, New Jersey | |||||
| Univ of Medicine & Dentistry of New Jersey / Univ Hosp | |||||
| Newark, New Jersey, United States, 071032714 | |||||
| United States, New York | |||||
| Bellevue Hosp / New York Univ Med Ctr | |||||
| New York, New York, United States, 10016 | |||||
| Mount Sinai Med Ctr / Pediatrics | |||||
| New York, New York, United States, 10029 | |||||
| United States, Tennessee | |||||
| Saint Jude Children's Research Hosp of Memphis | |||||
| Memphis, Tennessee, United States, 381052794 | |||||
| Regional Med Ctr at Memphis | |||||
| Memphis, Tennessee, United States, 38103 | |||||
| Puerto Rico | |||||
| San Juan City Hosp | |||||
| San Juan, Puerto Rico, 009367344 | |||||
| Study Chair: | Fridland A | |
| Study Chair: | Flynn P |
More Information
|
Rodman JH, Flynn PM, Robbins BL, Blanchard S, Jimenez E, Rodriguez J, Fridland A. Zidovudine pharmacokinetics and intracellular pharmacology of zidovudine in HIV-infected women and newborn infants. Conf Retroviruses Opportunistic Infect. 1999 Jan 31-Feb 4;6th:146 (abstract no 419)
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| Study ID Numbers: | ACTG 296 |
| First Received: | November 2, 1999 |
| Last Updated: | June 23, 2005 |
| ClinicalTrials.gov Identifier: | NCT00000830 |
| Health Authority: | United States: Federal Government |
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