Cholesterol Reduction in Seniors Program (CRISP) - Full Text View

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Cholesterol Reduction in Seniors Program (CRISP)

This study has been completed.

First Received: October 27, 1999 Last Updated: June 23, 2005 History of Changes

Sponsor:	National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:	National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:	NCT00000477

Purpose

To conduct a pilot study to determine whether lowering elevated serum cholesterol levels with 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG CoA) reductase inhibitors reduced mortality due to the sequelae of atherosclerotic cardiovascular disease in older men and women.

Condition	Intervention	Phase
Atherosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Hypercholesterolemia Myocardial Ischemia	Drug: lovastatin	Phase II

Study Type:	Interventional
Study Design:	Prevention, Randomized

Resource links provided by NLM:

Genetics Home Reference related topics: hypercholesterolemia

MedlinePlus related topics: Cholesterol Coronary Artery Disease Heart Diseases

Drug Information available for: Lovastatin

U.S. FDA Resources

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date:	July 1990
Estimated Study Completion Date:	June 1992

Show Detailed Description

Eligibility

Ages Eligible for Study:	65 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Men and women, ages 65 and older, with elevated low-density lipoprotein cholesterol levels between 159 and 221 mg/dl at entry.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00000477

Sponsors and Collaborators

National Heart, Lung, and Blood Institute (NHLBI)

Investigators

Investigator:	William Applegate	University of Tennessee
Investigator:	John Crouse	Bowman Gray School of Medicine
Investigator:	Donald Hunninghake	University of Minnesota
Investigator:	Robert Knopp	University of Washington
Investigator:	John LaRosa	George Washington University

More Information

Publications:

Stoy DB, Curtis RC, Dameworth KS, Dowdy AA, Hegland J, Levin JA, Sousoulas BG. The successful recruitment of elderly black subjects in a clinical trial: the CRISP experience. Cholesterol Reduction in Seniors Program. J Natl Med Assoc. 1995 Apr;87(4):280-7.

Davis CE, Applegate WB, Gordon DJ, Curtis RC, McCormick M. An empirical evaluation of the placebo run-in. Control Clin Trials. 1995 Feb;16(1):41-50.

LaRosa JC, Applegate W, Crouse JR 3rd, Hunninghake DB, Grimm R, Knopp R, Eckfeldt JH, Davis CE, Gordon DJ. Cholesterol lowering in the elderly. Results of the Cholesterol Reduction in Seniors Program (CRISP) pilot study. Arch Intern Med. 1994 Mar 14;154(5):529-39.

Santanello NC, Barber BL, Applegate WB, Elam J, Curtis C, Hunninghake DB, Gordon DJ. Effect of pharmacologic lipid lowering on health-related quality of life in older persons: results from the Cholesterol Reduction in Seniors Program (CRISP) Pilot Study. J Am Geriatr Soc. 1997 Jan;45(1):8-14.

Study ID Numbers:	66
Study First Received:	October 27, 1999
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00000477 History of Changes
Health Authority:	United States: Federal Government

Additional relevant MeSH terms:

Atherosclerosis
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Myocardial Ischemia
Arteriosclerosis
Pathologic Processes
Therapeutic Uses
Cardiovascular Diseases
Hypercholesterolemia
Dyslipidemias
Lovastatin
Arterial Occlusive Diseases
Hyperlipidemias

Heart Diseases
Metabolic Diseases
Antilipemic Agents
Vascular Diseases
Enzyme Inhibitors
Ischemia
Anticholesteremic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Pharmacologic Actions
Coronary Disease
Coronary Artery Disease
Lipid Metabolism Disorders

ClinicalTrials.gov processed this record on November 27, 2009