Inclusion Criteria:

• History of alcohol dependence and at least one year of abstinence from alcohol intake.
• Has a history of smoking 20 or more cigarettes per day for the prior year.
• Can read and write English.
• Stated ability to fully participate in the study and keep all scheduled appointments.
• Has provided written informed consent.
• General good health.

Exclusion Criteria:

• Recent history (within three months) of a clinically significant myocardial infarction, unstable angina pectoris, serious cardiac arrhythmia or any other medical condition which the physician investigator deems incompatible with study participation.
• Current major depression. A past history of major depression will not be an exclusionary criteria.
• Current or previous use of bupropion (Wellbutrin).
• Active non- nicotine drug dependence.
• Past or current history of bipolar disorder, pain disorder or psychosis, schizophrenia, or other major psychiatric disorders.
• Current medically indicated use of psychiatric drugs.
• Females who are pregnant, lactating, or likely to become pregnant during the first year which includes the nicotine patch and bupropion (Wellbutrin) phase.
• History of severe skin allergies or evidence of severe chronic skin disorders.
• Current use of nicotine containing medication or tobacco products other than cigarettes.
• Current use (within 30 days of initiation of patch therapy) of the following medications for smoking cessation: clonidine, buspirone, or doxepin.
• A predisposition to seizures.
• A history of or current diagnosis of anorexia nervosa or bulimia.
• Medical disorder that would interfere with the absorption, metabolism, or excretion of bupropion (Wellbutrin).