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Isoflurane at Subanesthetic Concentrations - 6

This study has been completed.

Sponsors and Collaborators: National Institute on Drug Abuse (NIDA)
University of Chicago
Information provided by: National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov Identifier: NCT00000254
  Purpose

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.


Condition Intervention Phase
Opioid-Related Disorders
Substance-Related Disorders
Drug: Nitrous oxide
Phase II

Drug Information available for:   Isoflurane    Nitrous oxide   

U.S. FDA Resources

Study Type:   Interventional
Study Design:   Treatment
Official Title:   Isoflurane at Subanesthetic Concentrations

Further study details as provided by National Institute on Drug Abuse (NIDA):

Primary Outcome Measures:
  • Pain intensity, pain bothersomeness
  • Mood
  • Psychomotor performance
  • Pain quality

Estimated Enrollment:   0
Study Start Date:   January 1995

  Eligibility
Ages Eligible for Study:   21 Years to 34 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Criteria

Please contact site for information.

  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00000254

Locations
United States, Illinois
University of Chicago, Anesthesia & Critical Care    
      Chicago, Illinois, United States, 60637

Sponsors and Collaborators

Investigators
Principal Investigator:     James Zacny, Ph.D.     University of Chicago    
  More Information


Study ID Numbers:   NIDA-08391-6, R01-08391-6
First Received:   September 20, 1999
Last Updated:   June 23, 2005
ClinicalTrials.gov Identifier:   NCT00000254
Health Authority:   United States: Federal Government

Study placed in the following topic categories:
Mental Disorders
Nitrous Oxide
Isoflurane
Substance-Related Disorders
Disorders of Environmental Origin
Opioid-Related Disorders

Additional relevant MeSH terms:
Disease
Physiological Effects of Drugs
Anesthetics
Central Nervous System Depressants
Pharmacologic Actions
Anesthetics, Inhalation
Pathologic Processes
Anesthetics, General
Analgesics, Non-Narcotic
Sensory System Agents
Therapeutic Uses
Peripheral Nervous System Agents
Analgesics
Central Nervous System Agents

ClinicalTrials.gov processed this record on December 03, 2008




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