Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3

This study has been completed.

First Received: September 20, 1999 Last Updated: November 3, 2005 History of Changes

Sponsors and Collaborators:	National Institute on Drug Abuse (NIDA) University of Chicago
Information provided by:	National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov Identifier:	NCT00000251

Purpose

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.

Condition	Intervention	Phase
Opioid-Related Disorders Substance-Related Disorders	Drug: Nitrous oxide	Phase II

Study Type:	Interventional
Study Design:	Treatment
Official Title:	Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide

Resource links provided by NLM:

Drug Information available for: Isoflurane Nitrous oxide

U.S. FDA Resources

Further study details as provided by National Institute on Drug Abuse (NIDA):

Primary Outcome Measures:

Psychomotor performance
Cognitive performance

Estimated Enrollment:	0
Study Start Date:	April 1994

Eligibility

Ages Eligible for Study:	21 Years to 32 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Please contact site for information.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00000251

Locations

United States, Illinois
University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States, 60637

Sponsors and Collaborators

National Institute on Drug Abuse (NIDA)

University of Chicago

Investigators

Principal Investigator:

James Zacny, Ph.D.

University of Chicago

More Information

No publications provided

Study ID Numbers:	NIDA-08391-3, R01-08391-3
Study First Received:	September 20, 1999
Last Updated:	November 3, 2005
ClinicalTrials.gov Identifier:	NCT00000251 History of Changes
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Nitrous Oxide
Disorders of Environmental Origin
Anesthetics
Central Nervous System Depressants
Opioid-Related Disorders
Anesthetics, Inhalation
Mental Disorders

Anesthetics, General
Analgesics, Non-Narcotic
Substance-Related Disorders
Isoflurane
Analgesics
Peripheral Nervous System Agents

Additional relevant MeSH terms:

Disease
Nitrous Oxide
Physiological Effects of Drugs
Disorders of Environmental Origin
Anesthetics
Central Nervous System Depressants
Opioid-Related Disorders
Pharmacologic Actions
Anesthetics, Inhalation
Pathologic Processes

Sensory System Agents
Analgesics, Non-Narcotic
Mental Disorders
Anesthetics, General
Therapeutic Uses
Substance-Related Disorders
Isoflurane
Peripheral Nervous System Agents
Analgesics
Central Nervous System Agents

ClinicalTrials.gov processed this record on July 02, 2009