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| Sponsored by: |
National Institute on Aging (NIA) |
| Information provided by: | National Institute on Aging (NIA) |
| ClinicalTrials.gov Identifier: | NCT00000176 |
Purpose
This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.
| Condition | Intervention | Phase |
|
Alzheimer Disease Memory Disorders |
Drug: Estrogen Drug: Estrogen and Progesterone |
Phase III |
| Genetics Home Reference related topics: | Alzheimer disease |
| MedlinePlus related topics: | Alzheimer's Disease Memory |
| Drug Information available for: | Progesterone |
| Study Type: | Interventional |
| Study Design: | Prevention, Randomized, Double-Blind, Placebo Control |
| Official Title: | Alzheimer's Disease Prevention Trial. A Multi-Center, Randomized, Double-Blind Placebo Controlled Trial of Estrogens to Prevent Alzheimer's Disease and Loss of Memory in Women. |
| Estimated Study Completion Date: | December 2010 |
PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.
Eligibility
| Ages Eligible for Study: | 65 Years and older |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| United States, Alabama | |||||
| University of Alabama | |||||
| Birmingham, Alabama, United States, 35294 | |||||
| United States, California | |||||
| University of California, Irvine | |||||
| Irvine, California, United States, 29697-4540 | |||||
| United States, Connecticut | |||||
| New England Center for Headache | |||||
| Stamford, Connecticut, United States, 06902-1249 | |||||
| United States, District of Columbia | |||||
| Howard University | |||||
| Washington, District of Columbia, United States, 20060 | |||||
| United States, Florida | |||||
| Lee Memorial Health System | |||||
| Fort Myers, Florida, United States, 33901 | |||||
| West Florida Regional Medical Center | |||||
| Pensacola, Florida, United States, 32514 | |||||
| North Broward Medical Center | |||||
| Pompano Beach, Florida, United States | |||||
| St. Mary's Medical Center | |||||
| West Palm Beach, Florida, United States, 33407 | |||||
| Tallahassee Memorial Health Center | |||||
| Tallahassee, Florida, United States, 32308 | |||||
| Wein Center | |||||
| Miami Beach, Florida, United States, 33140 | |||||
| Mayo Clinic Jacksonville | |||||
| Jacksonville, Florida, United States, 32225 | |||||
| United States, Maryland | |||||
| Johns Hopkins Bayview Medical Center | |||||
| Baltimore, Maryland, United States, 21224 | |||||
| United States, New Jersey | |||||
| Neurology Group of Bergen County | |||||
| Ridgewood, New Jersey, United States, 07450 | |||||
| United States, New York | |||||
| Burke Medical Research Institute | |||||
| White Plains, New York, United States, 10605 | |||||
| Columbia University | |||||
| New York, New York, United States, 10032 | |||||
| Cornell Medical Center, New York Presbyterian Medical Center | |||||
| New York, New York, United States | |||||
| New York United Hospital Medical Center | |||||
| Port Chester, New York, United States, 10573 | |||||
| United States, North Carolina | |||||
| Duke University Medical Center | |||||
| Durham, North Carolina, United States, 27710 | |||||
| United States, Oklahoma | |||||
| Clinical Pharmaceutical Trials | |||||
| Tulsa, Oklahoma, United States, 74104-5428 | |||||
| United States, Rhode Island | |||||
| Butler Hospital, Rhode Island Hospital | |||||
| Providence, Rhode Island, United States, 02906 | |||||
| United States, South Carolina | |||||
| Medical University of South Carolina | |||||
| North Charleston, South Carolina, United States, 29406 | |||||
| United States, Virginia | |||||
| Eastern Virginia Medical School | |||||
| Norfolk, Virginia, United States, 23507-1912 | |||||
| Principal Investigator: | Mary Sano, PhD | Mount Sinai School of Medicine |
More Information
| Study ID Numbers: | IA0018, RO 1AG15922-01 |
| First Received: | October 29, 1999 |
| Last Updated: | September 19, 2007 |
| ClinicalTrials.gov Identifier: | NCT00000176 |
| Health Authority: | United States: Federal Government |
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