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205 studies found for:    Primary Lateral Sclerosis

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Rank Status Study
1 Completed Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis
Conditions: Primary Lateral Sclerosis;   Hereditary Spastic Paraplegia;   Amyotrophic Lateral Sclerosis
Intervention:
2 Recruiting Screening and Natural History: Primary Lateral Sclerosis and Related Disorders
Conditions: Motor Nueron Disease;   Nervous System Diseases;   Muscle Spasticity;   Diffusion Tensor Imaging;   Disease Progression;   Evoked Potentials, Motor/Physiology
Intervention:
3 Completed Brain Function in Primary Lateral Sclerosis
Condition: Motor Neuron Disease
Intervention:
4 Active, not recruiting Brain Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis
Condition: Cerebral Cortex Dysfunction
Intervention:
5 Active, not recruiting Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study
Conditions: Motor Neuron Disease;   Primary Lateral Sclerosis
Intervention:
6 Recruiting Genetics of ALS: Identification of Genes With Roles in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS) and Amyotrophic Lateral Sclerosis (ALS) With Frontotemporal Dementia
Conditions: Amyotrophic Lateral Sclerosis;   Familial Amyotrophic Lateral Sclerosis;   Amyotrophic Lateral Sclerosis With Frontotemporal Dementia;   Lou Gehrig's Disease;   Motor Neuron Disease;   Primary Lateral Sclerosis
Intervention: Other: Genetic study of ALS families
7 Recruiting Collection of Blood Samples for DNA in Motor Neuron Disease
Condition: Motor Neuron Diseases
Intervention:
8 Completed Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease
Conditions: Motor Neuron Disease;   Amyotrophic Lateral Sclerosis;   Primary Lateral Sclerosis;   Progressive Muscular Atrophy
Intervention: Biological: Levetiracetam
9 Active, not recruiting Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)
Conditions: Amyotrophic Lateral Sclerosis;   Lou Gehrig's Disease;   Primary Lateral Sclerosis;   Nervous System Diseases;   Hereditary Spastic Paraparesis
Intervention: Other: No intervention
10 Completed Physiologic Studies of Spasticity
Conditions: Muscle Spasticity;   Healthy
Intervention:
11 Completed A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Condition: Amyotrophic Lateral Sclerosis
Interventions: Drug: Placebo;   Drug: 250 mg CK-2017357;   Drug: 500 mg CK-2017357
12 Recruiting Toxin Treatment for Amyotrophic Lateral Sclerosis (ALS) Related Sialorrhea
Conditions: Sialorrhea;   Amyotrophic Lateral Sclerosis
Interventions: Drug: Botox injection;   Drug: Placebo injection
13 Terminated Study of Pioglitazone in Patients With Amyotrophic Lateral Sclerosis
Condition: Amyotrophic Lateral Sclerosis
Interventions: Drug: pioglitazone;   Drug: placebo
14 Active, not recruiting Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis
Condition: Amyotrophic Lateral Sclerosis
Interventions: Drug: tauroursodeoxycholic acid (TUDCA);   Drug: Placebo
15 Recruiting Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis
Conditions: Amyotrophic Lateral Sclerosis 1;   Acquired Amyotrophic Lateral Sclerosis;   Amyotrophic Lateral Sclerosis
Intervention: Drug: Arimoclomol
16 Completed Growth Hormone in Amyotrophic Lateral Sclerosis
Condition: Amyotrophic Lateral Sclerosis
Interventions: Drug: Growth Hormone (Somatropin);   Drug: Placebo
17 Completed Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients With Amyotrophic Lateral Sclerosis (ALS)
Conditions: Amyotrophic Lateral Sclerosis;   Sialorrhea
Interventions: Drug: Botulinum toxin type B (Myobloc);   Procedure: Injection of salivary glands
18 Active, not recruiting Open-Label, Safety and Tolerability Extension Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) (CL211)
Condition: Amyotrophic Lateral Sclerosis
Intervention: Drug: KNS-760704
19 Completed Safety and Efficacy of AVP-923 in PBA Patients With ALS or MS
Condition: Pseudobulbar Affect (PBA)
Intervention: Drug: AVP-923
20 Unknown † Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis
Conditions: Amyotrophic Lateral Sclerosis;   Chronic Respiratory Failure
Interventions: Device: Non invasive ventilation delivered with one of the ventilator specifically designed for NIV and given to the patient by the home care providers;   Device: Non invasive ventilation
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† Indicates status has not been verified in more than two years