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Found 37 studies with search of: Open Studies | "Splenic Diseases"
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Rank Status Study
1 Recruiting Allogeneic Transplantation With Dose-Adjusted Busulfan
Conditions: Leukemia;   Lymphoma;   Multiple Myeloma;   Myelodysplastic Syndromes;   Agnogenic Myeloid Metaplasia
Intervention: Drug: Busulfan
2 Recruiting Phase I Dose-Escalation Trial of Clofarabine Followed by Escalating Doses of Fractionated Cyclophosphamide in Children With Relapsed or Refractory Acute Leukemias
Conditions: Myelodysplastic Syndrome;   Acute Myeloid Leukemia;   Myeloproliferative Disorders;   Acute Lymphocytic Leukemia;   Acute Promyelocytic Leukemia;   Acute Leukemia;   Chronic Myelogenous Leukemia;   Myelofibrosis;   Chronic Myelomonocytic Leukemia;   Juvenile Myelomonocytic Leukemia
Interventions: Drug: Clofarabine;   Drug: Cyclophosphamide
3 Recruiting Fludarabine and Total-Body Irradiation Followed By a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders
Conditions: Chronic Myeloproliferative Disorders;   Leukemia;   Myelodysplastic Syndromes;   Myelodysplastic/Myeloproliferative Diseases;   Secondary Myelofibrosis
Interventions: Drug: cyclosporine;   Drug: fludarabine phosphate;   Drug: mycophenolate mofetil;   Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation;   Procedure: peripheral blood stem cell transplantation;   Radiation: total-body irradiation
4 Recruiting Allogeneic Stem Cell Transplantation for Myelofibrosis
Condition: Myelofibrosis
Interventions: Drug: Busulfan;   Drug: Fludarabine;   Drug: Thymoglobulin (ATG)
5 Recruiting CEP-701 (Lestaurtinib) in Myelofibrosis
Conditions: Myelofibrosis;   Essential Thrombocythemia;   Polycythemia Vera
Intervention: Drug: CEP-701 (Lestaurtinib)
6 Recruiting Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease
Conditions: Leukemia;   Lymphoma;   Multiple Myeloma and Plasma Cell Neoplasm;   Myelodysplastic Syndromes;   Precancerous/Nonmalignant Condition;   Secondary Myelofibrosis
Interventions: Drug: busulfan;   Drug: cytarabine;   Drug: fludarabine phosphate;   Drug: mycophenolate mofetil;   Drug: tacrolimus;   Procedure: allogeneic hematopoietic stem cell transplantation;   Procedure: umbilical cord blood transplantation;   Radiation: total-body irradiation
7 Recruiting Study to Assess the Safety of AZD1480 in Patients With Myeloproliferative Diseases
Conditions: Primary Myelofibrosis (PMF);   Post-Polycythaemia Vera;   Essential Thrombocythaemia Myelofibrosis
Intervention: Drug: AZD1480
8 Recruiting A Phase I Study of SB1518 for the Treatment of Advanced Myeloid Malignancies
Conditions: Acute Myelogenous Leukemia;   Chronic Myelogenous Leukemia;   Chronic Myelomonocytic Leukemia;   Myelodysplastic Syndromes;   Myelofibrosis
Intervention: Drug: SB1518
9 Recruiting Pemetrexed Disodium in the Cerebrospinal Fluid of Patients With Leptomeningeal Metastases
Conditions: Chronic Myeloproliferative Disorders;   Leukemia;   Lymphoma;   Lymphoproliferative Disorder;   Metastatic Cancer;   Multiple Myeloma and Plasma Cell Neoplasm;   Myelodysplastic Syndromes;   Precancerous/Nonmalignant Condition;   Secondary Myelofibrosis;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: pemetrexed disodium;   Other: laboratory biomarker analysis;   Other: pharmacological study
10 Recruiting Cyclophosphamide and Busulfan Followed By Donor Stem Cell Transplant in Treating Patients With Myelofibrosis
Conditions: Chronic Myeloproliferative Disorders;   Secondary Myelofibrosis
Interventions: Drug: busulfan;   Drug: cyclophosphamide;   Drug: methotrexate;   Drug: tacrolimus;   Other: pharmacological study;   Procedure: allogeneic hematopoietic stem cell transplantation;   Procedure: peripheral blood stem cell transplantation
11 Recruiting Controlled Myelofibrosis Study With Oral Janus-associated Kinase (JAK) Inhibitor Treatment-II: The COMFORT-II Trial
Condition: Myelofibrosis
Interventions: Other: Best-available oral and/or parenteral therapies;   Drug: INCB018424
12 Recruiting Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease
Conditions: Chronic Myeloproliferative Disorders;   Graft Versus Host Disease;   Leukemia;   Lymphoma;   Multiple Myeloma and Plasma Cell Neoplasm;   Myelodysplastic Syndromes;   Myelodysplastic/Myeloproliferative Diseases;   Secondary Myelofibrosis;   Small Intestine Cancer
Interventions: Biological: therapeutic allogeneic lymphocytes;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: fludarabine phosphate;   Drug: tacrolimus;   Procedure: allogeneic hematopoietic stem cell transplantation;   Procedure: in vitro-treated peripheral blood stem cell transplantation;   Procedure: peripheral blood stem cell transplantation;   Radiation: total-body irradiation
13 Not yet recruiting Study of Oral Arsenic Trioxide With or Without Ascorbic Acid in Adults With Myelofibrosis
Condition: Primary Myelofibrosis
Intervention: Drug: Dose Escalating Arsenic Trioxide plus ascorbic Acid
14 Recruiting Polycythemia Vera, Myelofibrosis and Essential Thrombocythemia: Identification of PV, MF & ET Genes
Conditions: Polycythemia Vera;   Essential Thrombocythemia;   Myelofibrosis
Intervention:
15 Recruiting Research Tissue Bank
Conditions: Myelofibrosis;   Idiopathic Myelofibrosis;   Essential Thrombocythemia;   Polycythemia Vera
Intervention:
16 Recruiting A Phase 1/2 Study of Oral SB1518 in Subjects With Chronic Idiopathic Myelofibrosis
Conditions: Myelofibrosis;   Myeloproliferative Disorders;   Polycythemia Vera;   Essential Thrombocythemia
Intervention: Drug: SB1518
17 Recruiting Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS)
Conditions: ALPS;   Hypersplenism;   Lymphadenopathy
Interventions: Drug: Valproic Acid;   Procedure: CT Scan;   Procedure: Blood Sample
18 Recruiting Sibling Donor Peripheral Stem Cell Transplant or Sibling Donor Bone Marrow Transplant in Treating Patients With Hematologic Cancers or Other Diseases
Conditions: Chronic Myeloproliferative Disorders;   Graft Versus Host Disease;   Leukemia;   Lymphoma;   Myelodysplastic Syndromes;   Secondary Myelofibrosis
Interventions: Biological: filgrastim;   Procedure: allogeneic bone marrow transplantation;   Procedure: peripheral blood stem cell transplantation
19 Recruiting A Prospective Multicentre Phase II Trial of Zoledronic Acid in Patients With Myelofibrosis With Myeloid Metaplasia (MMM)
Conditions: Myelofibrosis;   Myeloid Metaplasia
Intervention: Drug: zoledronic acid
20 Recruiting Safety and Efficacy of Panobinostat in Patients With Primary Myelofibrosis
Conditions: Primary Myelofibrosis;   Post-Polycythemia Vera;   Post-Essential Thrombocytopenia
Intervention: Drug: Panobinostat

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