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80 studies found for:    Phenylalanine

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Rank Status Study
1 Recruiting Kuvan® in Phenylketonuria (PKU) Patients Less Than 4 Years Old
Condition: Phenylketonuria (PKU)
Interventions: Drug: Kuvan®;   Other: Phe-restricted diet
2 Completed Low Phenylalanine Diet for Mothers With Phenylketonuria (PKU)
Condition: Phenylketonuria
Intervention: Behavioral: Restricted phenylalanine diet
3 Terminated Boron Phenylalanine With or Without Mannitol in Treating Patients With Glioblastoma Multiforme
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: boron phenylalanine;   Drug: mannitol;   Other: biologic sample preservation procedure;   Radiation: radiation therapy treatment planning/simulation
4 Completed Study of a Phenylalanine Restricted Diet During Pregnancy to Prevent Symptoms in Offspring of Patients With Phenylketonuria
Condition: Phenylketonuria
Intervention: Behavioral: phenylalanine restricted diet
5 Completed
Has Results 		Study of Phenoptin to Increase Phenylalanine Tolerance in Phenylketonuric Children on a Phenylalanine-restricted Diet
Condition: Phenylketonurias
Interventions: Drug: Sapropterin Dihydrochloride;   Drug: Placebo
6 Active, not recruiting Effect of Kuvan on Neurocognitive Function, Blood Phenylalanine Level, Safety, and Pharmacokinetics in Children With PKU
Condition: Phenylketonuria
Intervention: Drug: sapropterin dihydrochloride
7 Completed A Phase 3, Multicenter, Open-Label Extension Study of Phenoptin in Subjects With PKU Who Have Elevated Phenylalanine Levels
Condition: Phenylketonurias
Intervention: Drug: sapropterin dihydrochloride
8 Completed
Has Results 		Study to Evaluate the Safety and Efficacy of Phenoptin™ in Subjects With Phenylketonuria Who Have Elevated Phenylalanine Levels
Condition: Phenylketonurias
Intervention: Drug: sapropterin dihydrochloride, 6R-BH4, tetrahydrobiopterin
9 Terminated Long-Term Tetrahydrobiopterin Treatment in PKU Patients of 0-18 Years - Study on Phenylalanine Tolerance and Safety
Condition: Phenylalanine Hydroxylase Deficiencies
Intervention: Drug: tetrahydrobiopterin (BH4)
10 Recruiting Novel Methodology to Measure Protein Accumulation
Condition: Aging
Intervention: Other: L[ring-13C6]phenylalanine
11 Active, not recruiting Ph II of Autologous Followed by Nonmyeloablative Allogeneic Transplantation Using TLI & ATG
Conditions: Transplantation, Homologous;   Transplantation, Autologous;   Multiple Myeloma;   Blood and Marrow Transplant (BMT)
Interventions: Procedure: Autologous/Allogeneic HCT;   Drug: cyclophosphamide;   Biological: filgrastim;   Drug: melphalan;   Procedure: peripheral blood stem cell transplantation;   Radiation: total nodal irradiation;   Biological: anti-thymocyte globulin;   Drug: cyclosporine;   Drug: mycophenolate mofetil;   Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation;   Other: laboratory biomarker analysis
12 Recruiting KIR Mismatched Haploidentical Donor Hematopoietic Progenitor Cell and NK Cell Transplantation for Hematologic Malignancy
Conditions: Leukemia;   Lymphoma
Interventions: Radiation: Total Lymphoid Irradiation;   Drug: Fludarabine;   Drug: Cyclophosphamide;   Drug: Thiotepa;   Drug: Melphalan;   Biological: HPC,A Infusion;   Biological: TC-NK Infusion;   Biological: G-CSF;   Drug: Mesna;   Device: CliniMACS
13 Not yet recruiting Therapy for Children With Advanced Stage Neuroblastoma
Condition: Neuroblastoma
Interventions: Drug: cyclophosphamide;   Drug: topotecan;   Biological: hu14.18K322A;   Procedure: peripheral blood stem cell harvest;   Procedure: surgical resection;   Drug: cisplatin;   Drug: etoposide;   Drug: doxorubicin;   Drug: vincristine;   Drug: busulfan;   Drug: melphalan;   Biological: peripheral blood stem cell transplantation;   Biological: natural killer cell infusion;   Radiation: radiation therapy;   Biological: GM-CSF;   Biological: G-CSF;   Drug: mesna;   Drug: levetiracetam;   Biological: interleukin-2;   Drug: Isotretinoin
14 Recruiting A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas
Conditions: Ewing Sarcoma;   Gastrointestinal Tumor;   Germ Cell Tumor;   Hepatic Tumor;   Lymphoma;   Wilms Tumor;   Rhabdoid Tumor;   Clear Cell Carcinoma;   Renal Cell Carcinoma;   Melanoma;   Neuroblastoma;   Rhabdomyosarcoma;   Non-rhabdomyosarcoma
Interventions: Drug: alemtuzumab;   Drug: fludarabine;   Drug: sirolimus;   Drug: Busulfan;   Drug: melphalan;   Biological: stem cells
15 Active, not recruiting Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma
Condition: Neuroblastoma
Interventions: Drug: carboplatin;   Drug: cyclophosphamide;   Drug: etoposide;   Drug: melphalan;   Drug: thiotepa
16 Completed Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma
Condition: Neuroblastoma
Interventions: Biological: filgrastim;   Drug: carboplatin;   Drug: cisplatin;   Drug: cyclophosphamide;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: isotretinoin;   Drug: melphalan;   Drug: topotecan hydrochloride;   Drug: vincristine sulfate;   Procedure: autologous bone marrow transplantation;   Procedure: bone marrow ablation with stem cell support;   Procedure: conventional surgery;   Procedure: peripheral blood stem cell transplantation;   Radiation: radiation therapy
17 Unknown † Kuvan Therapy in Phenylketonuria (PKU): The Effect of Blood Phenylalanine Concentration on Kuvan Response
Condition: Phenylketonuria
Intervention: Drug: Kuvan
18 Recruiting Phase 3 Open-label Study to Evaluate the Response and Safety of Kuvan® in Patients With Phenylketonuria
Condition: Phenylketonuria
Intervention: Drug: Kuvan®
19 Enrolling by invitation Phase 2 Study of Glycomacropeptide Versus Amino Acid Diet for Management of Phenylketonuria
Condition: Phenylketonuria
Interventions: Dietary Supplement: Amino Acid (AA) Diet Given First;   Dietary Supplement: Glycomacropeptide (GMP) diet given first
20 Recruiting Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation
Condition: Osteoarthritis
Interventions: Dietary Supplement: Essential amino acids;   Dietary Supplement: Alanine
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† Indicates status has not been verified in more than two years