Trial record 2 of 20 for:
vivo molecular AND cancer AND imaging
Molecular Imaging of Epidermal Growth Factor Receptor in Colorectal Neoplasia Using Confocal Laser Endomicroscopy
This study has been completed.
Information provided by (Responsible Party):
Yanqing Li, Shandong University
First received: January 18, 2011
Last updated: January 30, 2012
Last verified: January 2012
The study aims to:
- Achieve molecular imaging of EGFR in patients with colorectal neoplasia in vivo using confocal laser endomicroscopy.
- Compare the results of in vivo EGFR-specific molecular imaging with CLE and ex vivo immunohistochemistry .
||Time Perspective: Prospective
||In Vivo Molecular Imaging of Epidermal Growth Factor Receptor in Patients With Colorectal Neoplasia Using Confocal Laser Endomicroscopy
Biospecimen Retention: Samples With DNA
Take biospecimen during colonoscopy.
| Study Start Date:
| Study Completion Date:
| Primary Completion Date:
||July 2011 (Final data collection date for primary outcome measure)
Patients with colorectal carcinoma during conventional endoscopic imaging.
Patients with colorectal adenoma during conventional endoscopic imaging.
Various kinds of tumor markers have been shown to be over-expressed in colorectal cancer, including epidermal growth factor receptor(EGFR). The conventional detection method of EGFR expression in colorectal neoplasia is immunohistochemistry which is time-consuming, and the immunoreactivity can be affected by storage and fixation of tissues. Confocal laser endomicrosopy is a newly developed device which could identify the cellular and subcellular structures clearly with the magnification at×1000, making it possible to explore the physiological and pathological molecular mechanism of the gastrointestinal tract. So the study aims to achieve molecular imaging of EGFR in colorectal neoplasia in vivo using confocal laser endomicroscopy.
|Ages Eligible for Study:
||18 Years to 80 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
patients known to have large polypoid lesions in colon or rectum from previous examinations from outpatients and inpatients at Qilu Hospital were enrolled into the study
●Patients known to have large polypoid lesions in colon or rectum from previous examinations from outpatients and inpatients at Qilu Hospital were enrolled into the study
- Patients who are allergic to fluorescein sodium
- Patients with impaired cardiac, liver or renal function
- Patients who are unwilling to sign or give the informed consent form
- Patients with giant tumors or obvious GI tract bleeding which make it hard or impossible to observe the lesions
- Patients with coagulopathy
- Patients with pregnancy or breastfeeding
Please refer to this study by its ClinicalTrials.gov identifier: NCT01372189
|Department of Gastroenterology, Qilu Hospital, Shandong University
|Jinan, Shandong, China |
||Yanqing Li, PhD. MD.
||Department of Gastroenterology, Qilu Hospital
No publications provided
||Yanqing Li, Chief of the Department of Gastroenterology, Qilu Hospital, Shandong University, Shandong University
History of Changes
|Other Study ID Numbers:
|Study First Received:
||January 18, 2011
||January 30, 2012
||China: Ministry of Health
Keywords provided by Shandong University:
epidermal growth factor receptor
confocal laser endomicroscopy
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 13, 2014
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Digestive System Neoplasms
Neoplasms by Site
Molecular Mechanisms of Pharmacological Action
Digestive System Diseases