A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma (METEOR)

This study is currently recruiting participants.
Verified April 2014 by Exelixis
Sponsor:
Information provided by (Responsible Party):
Exelixis
ClinicalTrials.gov Identifier:
NCT01865747
First received: May 21, 2013
Last updated: April 8, 2014
Last verified: April 2014
  Purpose

The purpose of this study is to evaluate the effect of Cabozantinib (XL184) compared with Everolimus (Afinitor) on progression-free survival (PFS) and overall survival (OS) in subjects with advanced renal cell cancer that has progressed after prior VEGFR tyrosine kinase inhibitor therapy.


Condition Intervention Phase
Renal Cell Carcinoma
Drug: Cabozantinib (XL184)
Drug: Everolimus (Afinitor)
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Phase 3, Randomized, Controlled Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma That Has Progressed After Prior VEGFR Tyrosine Kinase Inhibitor Therapy

Resource links provided by NLM:


Further study details as provided by Exelixis:

Primary Outcome Measures:
  • Progression-free survival (PFS) [ Time Frame: up to 17 months ] [ Designated as safety issue: No ]
    PFS is measured from the date of randomization until the date of first documented disease progression or date of death from any cause, whichever comes first, assessed for up to 17 months.


Secondary Outcome Measures:
  • Overall Survival (OS) [ Time Frame: up to 36 months ] [ Designated as safety issue: No ]
    OS is measured from the time of randomization until death due to any cause assessed up to 36 months.

  • Objective Response Rate (ORR) [ Time Frame: up to 17 months ] [ Designated as safety issue: No ]
    ORR is the proportion of subjects, assessed up to 17 months, who have measurable disease at baseline and who have complete response (CR) or partial response (PR) at data cut off.


Estimated Enrollment: 650
Study Start Date: June 2013
Estimated Study Completion Date: August 2016
Estimated Primary Completion Date: September 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cabozantinib (XL184)
Cabozantinib (XL184) administered as an oral single tablet once daily.
Drug: Cabozantinib (XL184)
Active Comparator: Everolimus (Afinitor)
Everolimus (Afinitor) administered as an oral single tablet once daily.
Drug: Everolimus (Afinitor)

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Select Inclusion Criteria:

  1. Documented histological or cytological diagnosis of renal cell cancer with a clear-cell component.
  2. Measurable disease as determined by the investigator.
  3. Must have received at least one VEGFR-targeting TKI (eg, sorafenib, sunitinib, axitinib, pazopanib or tivozanib).
  4. Recovery from toxicities related to any prior treatments, unless AE(s) are clinically nonsignificant and/or stable on supportive therapy.
  5. Adequate organ and marrow function.
  6. Sexually active fertile subjects(male and female)must agree to use medically accepted methods of contraception during the course of the study and for 4 months after the last dose of study treatment.
  7. Female subjects of childbearing potential must not be pregnant at screening.

Select Exclusion Criteria:

  1. Prior treatment with everolimus, or any other specific or selective TORC1/PI3K/AKT inhibitor (eg, temsirolimus), or cabozantinib.
  2. Receipt of any type of small molecule kinase inhibitor (including investigational kinase inhibitor) within 2 weeks before randomization.
  3. Receipt of any type of anticancer antibody (including investigational antibody) within 4 weeks before randomization.
  4. Radiation therapy for bone metastasis within 2 weeks, any other external radiation therapy within 4 weeks before randomization. Systemic treatment with radionuclides within 6 weeks before randomization. Subjects with clinically relevant ongoing complications from prior radiation therapy are not eligible.
  5. Known brain metastases or cranial epidural disease unless adequately treated with radiotherapy and/or surgery and stable for at least 3 months before randomization.
  6. Concomitant anticoagulation at therapeutic doses with oral anticoagulants or platelet inhibitors.
  7. Chronic treatment with corticosteroids or other immunosuppressive agents.
  8. Serious illness other than cancer.
  9. Major surgery within 3 months before randomization. Complete wound healing from major surgery must have occurred 1 month before randomization and from minor surgery at least 10 days before randomization.
  10. Pregnant or lactating females.
  11. Diagnosis of another malignancy within 2 years before randomization, except for superficial skin cancers, or localized, low grade tumors.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01865747

Contacts
Contact: Exelixis Clinical Trials 1-888- EXELIXIS (888-393-5494) druginfo@exelixis.com
Contact: Backup or International 650-837-7400

  Hide Study Locations
Locations
United States, Alabama
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Birmingham, Alabama, United States
Contact: Alfreida Lewis    205-975-9025    fredalewis@uab.edu   
United States, Arizona
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Gilbert, Arizona, United States, 85234
Contact: Shannon Johnson    480-256-3333    shannon.johnson@bannerhealth.com   
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Scottsdale, Arizona, United States, 85259
Contact: Eric Siebeneck    480-307-6253    siebeneck.eric@mayo.edu   
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Tucson, Arizona, United States, 85724
Contact: Singh Parminder    520-626-2218    psingh@uacc.arizona.edu   
United States, California
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Duarte, California, United States, 91010
Contact: Sumanta Pal    626-256-4673 ext 69200    spal@coh.org   
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La Jolla, California, United States, 92093
Contact: Arlene Araneta    858-822-5374    aaraneta@ucsd.edu   
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Los Angeles, California, United States, 90095
Contact: Nazy Zomorodian    310-794-3550    nzomorodian@mednet.ucla.edu   
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Los Angeles, California, United States, 90048
Contact: Nancy Moldawer    310-248-7698    nancy.moldawer@cshs.org   
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Vallejo, California, United States, 94589
United States, Colorado
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Aurora, Colorado, United States, 80045
Contact: Nicole Chronister    720-848-0602    nicole.chronister@ucdenver.edu   
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Denver, Colorado, United States, 80218
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New Haven, Connecticut, United States, 06520
United States, Florida
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Boca Raton, Florida, United States, 33486
Contact: Shirley Daniel    561-955-4800    sdaniel@brrh.com   
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Fort Myers, Florida, United States, 33908
Contact: Research Office    239-274-9930    clinicaltrials@flcancer.com   
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Miami, Florida, United States, 33136
Contact: Zvi Leibovici    305- 243-3700    z.leibovici@med.miami.edu   
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Contact: Jodi Carlson    913-945-7552    jcarlson@kumc.edu   
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Baltimore, Maryland, United States, 21201
Contact: Michele Besche    410-328-8610    mbesche@umm.edu   
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Baltimore, Maryland, United States, 21287
Contact: Rana Sullivan    410-614-7287    tomalra@jhmi.edu   
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Contact: Connie Harkness    (313) 916-1048    charkne1@hfhs.org   
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Contact: Chris Grant    314-747-3575    cgrant@dom.wustl.edu   
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Contact: Alison Kannon    919-966-4773    alison_Kannon@med.unc.edu   
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Contact: Rowena Santillan    713-467-1722    rowena.santillan@usoncology.com   
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Contact: Cherie Perez    713-563-1602    caperez@mdanderson.org   
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San Antonio, Texas, United States, 78229
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Contact: Dholani Zarook    801-587-4776    dholani.zarook@hci.utah.edu   
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Contact: Nichole Real    206-288-7476    nar4@uw.edu   
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Yakima, Washington, United States, 98902
Argentina
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Contact: Pedro Alvarez    '+54 9 221 5067890    peugeal@hotmail.com.ar   
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Mar Del Plata, Argentina, B7600LTO
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Australia, New South Wales
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Concord, New South Wales, Australia, 2139
Contact: Cathy Xu    612-9767 7033    catherine.xu@sswahs.nsw.gov.au   
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Contact: Lalith Ratnayake    612-9355-5615    lratnayake@stvincents.com.au   
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Randwick, New South Wales, Australia, 2031
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Australia, Queensland
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Milton, Queensland, Australia, 4064
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Australia, South Australia
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Adelaide, South Australia, Australia, 5000
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Australia, Tasmania
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Hobart, Tasmania, Australia, 7000
Contact: Sue Davoren    613 6222 8120    Sue.Davoren@dhhs.tas.gov.au   
Australia, Victoria
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Bentleight East, Victoria, Australia, 3165
Contact: Christine Pool    613 9928 8253    christine.poole@southernhealth.org.au   
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Box Hill, Victoria, Australia, 3128
Contact: Yvonne Chan    613 9095 2464    yvonne.chan@easternhealth.org.au   
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Wodonga, Victoria, Australia, 3690
Contact: Julie Croft    61260515325    jcroft@bordermedonc.com.au   
Austria
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Linz, Oberösterreich, Austria, 4010
Contact: Sandra Sobota    +4373276774085    sandra.sobota@bhs.at   
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Wien, Austria, 1090
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Belgium
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Bonheiden, Antwerpen, Belgium, 2820
Contact: Ann Pauwels    +3214504625    ann.pauwels@imelda.be   
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Brasschaat, Antwerpen, Belgium, 2930
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Bruxelles, Brussels, Belgium, 1000
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Leuven, Vlaams Brabant, Belgium, 3000
Contact: Ingeborg Wauters    +3216346912    ingeborg.wauters@uzleuven.be   
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Roeselare, West-Vlaanderen, Belgium, 8800
Contact: Rina Talpe    +3251237511    rtalpe@hhr.be   
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Antwerpen, Belgium, 2020
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Liege, Belgium, 4000
Contact: Maude Piron    +3243668250    mpiron@chu.ulg.ac.be   
Brazil
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Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
Contact: Carlos Barrios    +55 51 33203039    chbe@via-rs.net   
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Sao Paulo, São Paulo, Brazil, 01246 000
Contact: Carlos Dzik    +55 11 31550681    dzik@terra.com.br   
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Rio de Janeiro, Brazil, 22260-020
Contact: Daniel Herchenhorn    +55 21 32331413    herchenhorn@hotmail.com   
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Sao Paulo, Brazil, 01323-001
Contact: Fabio Schutz    55 11 3505 6693    fabioschutz@gmail.com   
Canada, Alberta
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Calgary, Alberta, Canada, T2N 4N2
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Edmonton, Alberta, Canada, T6G 1Z2
Contact: Daphne Willan    780-432-8788    daphne.willan@albertahealthservices.ca   
Canada, British Columbia
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Vancouver, British Columbia, Canada, V5Z 4E6
Contact: Christian Kollmannsberger    604-877-6000 ext 2734    ckollmannsberger@bccancer.bc.ca   
Canada, Manitoba
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Winnepeg, Manitoba, Canada, R3A 1R9
Canada, Nova Scotia
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Halifax, Nova Scotia, Canada, B3H 1V7
Contact: Lori Wood    902-473-6106    lori.wood@cdha.nshealth.ca   
Canada, Ontario
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Hamilton, Ontario, Canada, L8V 5C2
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Kingston, Ontario, Canada, K7L 5P9
Contact: Stephanie Willing    613-549-6666    willings@kgh.kari.net   
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London, Ontario, Canada, N6A 4L6
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Oshawa, Ontario, Canada, L1G 2B9
Contact: RSM Durham Regional Cancer Centre    905-576-8711      
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Ottawa, Ontario, Canada, K1H 8L6
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Toronto, Ontario, Canada, M4N 3M5
Contact: Nesan Bandail    416-480-5000 ext 5739    nesan.bandali@sunnybrook.ca   
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Toronto, Ontario, Canada, M5G 2N2
Canada, Quebec
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Montreal, Quebec, Canada, H2L 4M1
Contact: Denis Soulieres    514-890-5000 ext 25381    denis.soulieres.chum@ssss.gouv.qc.ca   
Canada, Saskatchewan
Recruiting
Saskatoon, Saskatchewan, Canada, S7N 4H4
Contact: Rose Jackson    306 655-2777    rose.jackson@saskcancer.ca   
Chile
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Santiago, Chile
Contact: Osvaldo Arén Frontera    +56 9 9158 0175    oaren@incancer.cl   
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Santiago, Chile
Contact: Pamela Salman,    +56 224457307    pvsalman@gmail.com   
Czech Republic
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Olomouc, Olomoucký kraj, Czech Republic, 775 20
Contact: Lenka Knourkova    +420588444717      
Contact: Vendula Svendova    +420588444717      
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Brno, Czech Republic, 656 91
Contact: Pavlina Prosecka    +420543183088    pavlina.prosecka@fnusa.cz   
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Prague, Czech Republic, 128 08
Contact: Petra Kalinova    +420224 966405    petra.kalinova@vfn.cz   
Denmark
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Herlev, Hovedstaden, Denmark, DK-2730
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Aarhus, Midtjylland, Denmark, DK-8000
Contact: Helle Hogstad-Kelstrup    +4578466011    helkel@rm.dk   
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Odense, Syddanmark, Denmark, DK-5000
Contact: Liselotte Jeppesen    +4565411636    liselotte.jeppesen@ouh.regionsyddanmark.dk   
Finland
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Helsinki, Finland, 290
Contact: Mia Viskari    3.58504E+11    mia.viskari@hus.fi   
France
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Caen, Calvados, France, 14076
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Besancon, Doubs, France, 25030
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Bordeaux, Gironde, France, 33075
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Toulouse, Haute-Garonne, France, 31052
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Rennes, Ille-et-Vilaine, France, 35042
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Nantes, Loire-Atlantique, France, 44805
Contact: Valerie Herbault       valerie.herbault@ico.unicancer.fr   
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Lyon, Rhône, France, 96008
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Le Mans, Sarthe, France, 72000
Contact: Melanie Peridy       valerie.herbault@ico.unicancer.fr   
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Villejuif, Val-de-Marne, France, 94805
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Marseille, France, 13273
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Paris, France, 75908
Germany
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Freiburg, Baden Wuttemberg, Germany, 79106
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Tubingen, Baden-Württemberg, Germany, 72076
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Ulm, Baden-Württemberg, Germany, 89075
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Erlangen, Bayern, Germany, 91054
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Aachen, Nordrhein-Westfalen, Germany, 52074
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Essen, Nordrhein-Westfalen, Germany, 45122
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Munster, Nordrhein-Westfalen, Germany, 48149
Contact: Barbara Thielen    +49434 243-9900    sylvia.dondl@med.uni-muenchen.de   
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Mainz, Rheinland-Pfalz, Germany, 55131
Recruiting
Jena, Thuringen, Germany, 99089
Contact: Katharina Schaarschmidt    +49 3641/ 9 35 264    katharina.schaarschmidt@med.uni-jena.de   
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Erfurt, Thüringen, Germany, 99089
Recruiting
Berlin, Germany, 12200
Contact: Anika Biniszkiewicz    +4930 84452329    anika.biniszkiewicz@charite.de   
Recruiting
Dresden, Germany, 01307
Contact: Daniela Höyer    +493514584425    daniela.hoeyer@uniklinikum-dresden.de   
Contact: Xenia Lück    +493514584425    xenia.lueck@uniklinikum-dresden.de   
Recruiting
Frankfurt am Main, Germany, 60590
Contact: Angelika Hipfel    +496963017969    hipfel@em.uni-frankfurt.de   
Recruiting
Guetersloh, Germany, 33332
Contact: Clauida Depenbusch    +4952418324382    claudia.depenbusch@klinikum-guetersloh.de   
Recruiting
Hamburg, Germany, 20246
Contact: Christine Heinzer    +49 40 741054836    c.heinzer@uke.de   
Recruiting
Hannover, Germany, 30605
Contact: Kathleen Schütte    +49 511-532-9196    schuette.kathleen@mh-hannover.de   
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Munich, Germany, 81377
Contact: Silvia L Dondt    +498970957883    sylvia.dondl@med.uni-muenchen.de   
Hungary
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Budapest, Hungary, 1122
Contact: Adrienn Heisz    +36 20 966 2944    adrienn.heisz@coordination.hu   
Recruiting
Szolnok, Hungary, 5004
Contact: Aniko Eke    +36 56 503 669    eke.aniko@teletechnik.hu   
Ireland
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Dublin, Ireland, 7
Contact: Martina Smith    +35318034835    msmith@mater.ie   
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Dublin, Ireland, 24
Italy
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Meldola, Emilia-Romagna, Italy, 47014
Contact: Fabbri Francesca    +39 0594224383    francesca.fabbri@irst.emr.it   
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Modena, Emilia-Romagna, Italy, 41124
Contact: Pasquale Mighali    +39 0594224383    pasquale.mighali@unimore.it   
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Ravenna, Emilia-Romagna, Italy, 48100
Contact: Federica Zumaglini    +390544286223    f.zumaglini@ausl.ra.it   
Recruiting
Rome, Lazio, Italy, 00128
Contact: Teresa Grassani    +39 06225411160    t.grassani@unicampus.it   
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Rome, Lazio, Italy, 00152
Contact: Eugenio Donato Di Paola    +39 0658704356      
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Genova, Liguria, Italy, 16132
Contact: Linda Zinoli    +39 0105600549    datamanager.omb@istge.it   
Recruiting
Cremona, Lombardia, Italy, Lombardia
Contact: Silvia Lazzarelli    +39 0372408035    s.lazzarelli@ospedale.cremona.it   
Not yet recruiting
Bari, Puglia, Italy, 70124
Recruiting
Arezzo, Toscana, Italy, 52100
Contact: Samanta Capacci    +39 0575 255434    samanta.capaci@usl8.toscana.it   
Recruiting
Terni, Umbria, Italy, 05100
Contact: Eleonora Morichetti    +39 0744205631    elemor03@libero.it   
Not yet recruiting
Pavia, Italy, 27100
Korea, Republic of
Recruiting
Seoul, Korea, Republic of
Contact: Hye Jin Jang    +82 2 3410 6859    hyejin1217.jang@samsung.com   
Recruiting
Seoul, Korea, Republic of
Contact: Sumi Park    822-3010-7349    sumipark@amc.seoul.kr   
Recruiting
Seoul, Korea, Republic of, 110-744
Contact: Seo Hee Chae    : (822) 20720832    shlee119@snu.ac.kr   
Recruiting
Seoul, Korea, Republic of, 120-752
Contact: Hyon Jung Park    822 222-8805 ext 4    hjwwjd@yuhs.ac   
Netherlands
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Maastricht, Limburg, Netherlands, 6229 HX
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Amsterdam, Noord-Holland, Netherlands, 1066 CX
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Leiden, Zuid-Holland, Netherlands, 2333 ZA
Contact: Jeanne van Steijn    +3171-5269111    a.q.m.j.van_steijn-van_tol@lumc.nl   
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Rotterdam, Zuid-Holland, Netherlands, 3045 PM
Poland
Recruiting
Bialystok, Podlaskie, Poland, 15-027
Contact: Bogumila Czartoryska-Arlukowicz    +48856646795    barlukowicz@poczta.onet.pl   
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Gdansk, Pomorskie, Poland, 80-210
Contact: Joanna Karczewska    +48587324810    bk@wco.gda.pl   
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Poznan, Wielkopolskie, Poland, 60-569
Recruiting
Warsaw, Poland, 04-909
Portugal
Recruiting
Lisbon, Portugal, 1649-035
Contact: Ricardo Pires    +351217805097      
Recruiting
Lisbon, Portugal, 1500-650
Contact: Rita Alcoforado    +351963096422    rita.alcoforado@hospitaldaluz.pt   
Contact: Rita Eça    +351963096422    rheca@hospitaldaluz.pt   
Recruiting
Porto, Portugal, 200-072
Russian Federation
Recruiting
Moscow, Russian Federation, 115478
Recruiting
Omsk, Russian Federation, 644013
Contact: Oleg Leonov    +79136043222    leonov_oleg@mail.ru   
Recruiting
St. Petersburg, Russian Federation, 196247
Recruiting
Yaroslavl, Russian Federation, 150040
Contact: Marina Shultishova    +79038243111    mshultishova@rambler.ru   
Slovakia
Recruiting
Presov, Slovakia, 08001
Contact: Maria Mincikova    +421908448630    maria.mincikova@gmail.com   
Recruiting
Zilina, Slovakia, 01207
Contact: Edita Solarikova    +421415110782    solarikova@fnspza.sk   
Spain
Recruiting
Oviedo, Asturias, Spain, 33006
Contact: Susana Abadia    +34935537134    sabadia@santpau.cat   
Recruiting
Barcelona, Cataluna, Spain, 08025
Contact: Susana Abadia    +34935537134    sabadia@santpau.cat   
Recruiting
Badalona, Cataluña, Spain, 08003
Contact: Marta Maciá    +34932483609    mmacia@pardesalutmar.cat   
Recruiting
L'Hospitalet de Llobregat, Cataluña, Spain, 08907
Contact: Christina Feliu    +34932607822    cfeliu@iconcologia.net   
Recruiting
Barcelona, Spain, 08035
Recruiting
Madrid, Spain, 28922
Contact: Sofia Perea    +34917567984    sofiaperea@hospitaldemadrid.com   
Recruiting
Madrid, Spain, 28034
Contact: Sara Lavín    +34 91 3368263    slavin.hrc@salud.madrid.org   
Recruiting
Madrid, Spain, 28041
Contact: Jonathan Lucas    +3491390833    unidadc@h12o.es   
Recruiting
Málaga, Spain, Málaga
Contact: Eva Saiz    +34609250477    datamanagerhcuvv@yahoo.es   
Not yet recruiting
Santiago de Compostela, Spain, 15706
Recruiting
Seville, Spain, 28050
Contact: Macarena Cruz    +34955009025    ensayosclinicos.hvr.sspa@juntadeandalucia.es   
Recruiting
Valencia, Spain, 46010
Contact: Jessica Fraile    +34650025544    fraile_jes@gva.es   
Sweden
Recruiting
Lund, Skane lan, Sweden, SE-22185
Contact: Irene Schönström    +4646178559    irene.schonstrom@skane.se   
Recruiting
Stockholm, Sodermanlands lan, Sweden
Contact: Johanna Uggla    +46851779822    johanna.uggla@karolinska.se   
Recruiting
Umea, Sweden
Contact: Margareta Lundgren    +46907853535    margareta.lundgren@vll.se   
Taiwan
Recruiting
Taichung, Taiwan
Contact: Yen-Chuan Ou    +886.4.23592525 ext 5136    ycou@vghtc.gov.au   
Recruiting
Taipei, Taiwan
Contact: Chia-Chi Lin    '+886-2-23123456 ext 67851    cclin1@ntu.edu.tw   
Recruiting
Taipei, Taiwan
Contact: Hsiao-Jen Chung    '+886-2-2-28757519 ext 304    hjchung@vghtpe.gov.tw   
Turkey
Recruiting
Ankara, Turkey, 6500
Recruiting
Gaziantep, Turkey, 27100
Not yet recruiting
Istanbul, Turkey, 34365
Recruiting
Izmir, Turkey, 35100
United Kingdom
Not yet recruiting
Birmingham, England, United Kingdom
Not yet recruiting
Bristol, England, United Kingdom, BS2 8ED
Recruiting
Guildford, England, United Kingdom, GU2 7XX
Contact: Fiona Archer    +44148368856    f.archer@surrey.ac.uk   
Recruiting
London, England, United Kingdom, EC1A 7BE
Not yet recruiting
London, England, United Kingdom, SE1 9ER
Not yet recruiting
London, England, United Kingdom, W6 8RF
Recruiting
London, England, United Kingdom
Not yet recruiting
Manchester, England, United Kingdom, M20 4BX
Recruiting
Northwood, England, United Kingdom, HA6 2RN
Contact: Lisa Clark    +441923844763    i.clark2@nhs.net   
Recruiting
Wirral, England, United Kingdom, CH63 4JY
Contact: Laurie Lomax    +441513341155    laurie.lomax@clatterbridgecc.nhs.uk   
Recruiting
Edinburgh, Scotland, United Kingdom, EH4 2XU
Contact: Fiona Gardiner    +441315371029    fiona.gardiner@nhslothian.scot.nhs.uk   
Recruiting
Glasgow, Scotland, United Kingdom
Contact: Ruth Orr    +441413017207    ruth.orr@glasgow.ac.uk   
Sponsors and Collaborators
Exelixis
  More Information

No publications provided

Responsible Party: Exelixis
ClinicalTrials.gov Identifier: NCT01865747     History of Changes
Other Study ID Numbers: XL184-308
Study First Received: May 21, 2013
Last Updated: April 8, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by Exelixis:
renal cell cancer
kidney
vascular endothelial growth factor receptor 2 (VEGFR2)
tyrosine kinase inhibitor
hepatocyte growth factor receptor protein (MET)
von Hippel-Lindau gene

Additional relevant MeSH terms:
Carcinoma
Carcinoma, Renal Cell
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Adenocarcinoma
Kidney Neoplasms
Urologic Neoplasms
Urogenital Neoplasms
Neoplasms by Site
Kidney Diseases
Urologic Diseases
Everolimus
Sirolimus
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Pharmacologic Actions
Antibiotics, Antineoplastic
Antineoplastic Agents
Therapeutic Uses
Antifungal Agents
Anti-Infective Agents
Anti-Bacterial Agents

ClinicalTrials.gov processed this record on April 16, 2014